Matches in SemOpenAlex for { <https://semopenalex.org/work/W561956948> ?p ?o ?g. }
- W561956948 endingPage "457" @default.
- W561956948 startingPage "450" @default.
- W561956948 abstract "Abstract The aim of this work was to prepare and evaluate the capability of zein nanoparticles for oral drug delivery. More particularly, in this work, the ability of these nanoparticles to improve the oral bioavailability of folic acid is reported. The nanoparticles were prepared by a desolvation process, followed by purification via ultrafiltration and drying in a spray-drier apparatus. The resulting nanoparticles displayed a mean size close to 200 nm with negative zeta potential and a payload of 54 μg folic acid per mg nanoparticle. From the in vitro release studies, it was observed that folic acid was only released from nanoparticles in simulated intestinal conditions. In vivo biodistribution studies, with radiolabelled or fluorescently marked nanoparticles, revealed that nanoparticles remained within the gut and were capable of interacting with the protective mucus layer of the jejunum. For the pharmacokinetic study, folic acid was orally administered to rats as a single dose of 1 mg/kg. The relatively oral bioavailability of folic acid, when encapsulated in zein nanoparticles, was around 70%: two-times higher than the value obtained with an aqueous solution of the vitamin. This fact might be explained by the mucoadhesive properties of these nanoparticles." @default.
- W561956948 created "2016-06-24" @default.
- W561956948 creator A5003732639 @default.
- W561956948 creator A5011699959 @default.
- W561956948 creator A5013934560 @default.
- W561956948 creator A5029219877 @default.
- W561956948 creator A5070668487 @default.
- W561956948 creator A5076579189 @default.
- W561956948 date "2015-12-01" @default.
- W561956948 modified "2023-09-24" @default.
- W561956948 title "Zein nanoparticles for oral folic acid delivery" @default.
- W561956948 cites W100823833 @default.
- W561956948 cites W102919070 @default.
- W561956948 cites W1483538570 @default.
- W561956948 cites W1978424578 @default.
- W561956948 cites W1980468509 @default.
- W561956948 cites W1985004872 @default.
- W561956948 cites W1990703828 @default.
- W561956948 cites W1991424945 @default.
- W561956948 cites W1992037149 @default.
- W561956948 cites W2000398244 @default.
- W561956948 cites W2015573541 @default.
- W561956948 cites W2022485771 @default.
- W561956948 cites W202561933 @default.
- W561956948 cites W2028352008 @default.
- W561956948 cites W2036678009 @default.
- W561956948 cites W2038932660 @default.
- W561956948 cites W2043467091 @default.
- W561956948 cites W2052152548 @default.
- W561956948 cites W2053322526 @default.
- W561956948 cites W2055604901 @default.
- W561956948 cites W2055917729 @default.
- W561956948 cites W2056259794 @default.
- W561956948 cites W2059955514 @default.
- W561956948 cites W2063369562 @default.
- W561956948 cites W2073235279 @default.
- W561956948 cites W2083454312 @default.
- W561956948 cites W2098006722 @default.
- W561956948 cites W2115157913 @default.
- W561956948 cites W2123059347 @default.
- W561956948 cites W2124556550 @default.
- W561956948 cites W2125718465 @default.
- W561956948 cites W2129907789 @default.
- W561956948 cites W2154389444 @default.
- W561956948 cites W2172179400 @default.
- W561956948 cites W2331914560 @default.
- W561956948 cites W2333799339 @default.
- W561956948 cites W4229515057 @default.
- W561956948 cites W96540192 @default.
- W561956948 doi "https://doi.org/10.1016/j.jddst.2015.06.012" @default.
- W561956948 hasPublicationYear "2015" @default.
- W561956948 type Work @default.
- W561956948 sameAs 561956948 @default.
- W561956948 citedByCount "71" @default.
- W561956948 countsByYear W5619569482016 @default.
- W561956948 countsByYear W5619569482017 @default.
- W561956948 countsByYear W5619569482018 @default.
- W561956948 countsByYear W5619569482019 @default.
- W561956948 countsByYear W5619569482020 @default.
- W561956948 countsByYear W5619569482021 @default.
- W561956948 countsByYear W5619569482022 @default.
- W561956948 countsByYear W5619569482023 @default.
- W561956948 crossrefType "journal-article" @default.
- W561956948 hasAuthorship W561956948A5003732639 @default.
- W561956948 hasAuthorship W561956948A5011699959 @default.
- W561956948 hasAuthorship W561956948A5013934560 @default.
- W561956948 hasAuthorship W561956948A5029219877 @default.
- W561956948 hasAuthorship W561956948A5070668487 @default.
- W561956948 hasAuthorship W561956948A5076579189 @default.
- W561956948 hasBestOaLocation W5619569482 @default.
- W561956948 hasConcept C126322002 @default.
- W561956948 hasConcept C155672457 @default.
- W561956948 hasConcept C171250308 @default.
- W561956948 hasConcept C185592680 @default.
- W561956948 hasConcept C192562407 @default.
- W561956948 hasConcept C2992130864 @default.
- W561956948 hasConcept C71924100 @default.
- W561956948 hasConceptScore W561956948C126322002 @default.
- W561956948 hasConceptScore W561956948C155672457 @default.
- W561956948 hasConceptScore W561956948C171250308 @default.
- W561956948 hasConceptScore W561956948C185592680 @default.
- W561956948 hasConceptScore W561956948C192562407 @default.
- W561956948 hasConceptScore W561956948C2992130864 @default.
- W561956948 hasConceptScore W561956948C71924100 @default.
- W561956948 hasFunder F4320322930 @default.
- W561956948 hasLocation W5619569481 @default.
- W561956948 hasLocation W5619569482 @default.
- W561956948 hasOpenAccess W561956948 @default.
- W561956948 hasPrimaryLocation W5619569481 @default.
- W561956948 hasRelatedWork W1066196250 @default.
- W561956948 hasRelatedWork W1976195758 @default.
- W561956948 hasRelatedWork W1977013938 @default.
- W561956948 hasRelatedWork W2094226443 @default.
- W561956948 hasRelatedWork W2275341195 @default.
- W561956948 hasRelatedWork W2518360665 @default.
- W561956948 hasRelatedWork W2899084033 @default.
- W561956948 hasRelatedWork W3016721682 @default.
- W561956948 hasRelatedWork W4248400276 @default.