Matches in SemOpenAlex for { <https://semopenalex.org/work/W56215835> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W56215835 endingPage "70" @default.
- W56215835 startingPage "667" @default.
- W56215835 abstract "To investigate gene mutations of epidermal growth factor receptor (EGFR) and K-ras in Chinese patients with non-small cell lung cancer (NSCLC) and its clinicopathological significance, and to analyze the correlation between these mutations and tumor response to erlotinib treatment.Mutations of exons 18, 19, 20 and 21 of the EGFR and codons 12, 13 of the K-ras in 301 cases of NSCLC were detected by PCR-amplification and gene sequencing. The relationship between the mutations and clinicopathological characteristics of the 301 patients was analyzed.EGFR mutations were present in 32.9% (99/301) of the samples: 3 mutation in exon 18, 59 in exon 19, 2 in exon 20, and 35 in exon 21. Mutations of K-ras were present in 4.7% (14/301) of the samples: 13 in codon 12 and 1 in codon 13. EGFR mutations were never found in tumors with K-ras mutations, suggesting a mutually exclusive relationship. EGFR mutations were more common in adenocarcinomas, non-smokers and females. Seven out of 10 erlotinib-treated patients with disease control carried EGFR mutation.The frequency of EGFR mutation in Chinese NSCLC patients is higher than that in Westerners, but the frequency of K-ras mutation is quite opposite. Combined detection of EGFR gene and K-ras gene mutation may help clinicians to choose patients who may gain benefit from EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment, and to predict their response to erlotinib treatment and prognosis." @default.
- W56215835 created "2016-06-24" @default.
- W56215835 creator A5004324240 @default.
- W56215835 creator A5009604094 @default.
- W56215835 creator A5036726873 @default.
- W56215835 creator A5043935779 @default.
- W56215835 creator A5045422255 @default.
- W56215835 creator A5050921331 @default.
- W56215835 creator A5055687694 @default.
- W56215835 creator A5081681814 @default.
- W56215835 date "2010-09-01" @default.
- W56215835 modified "2023-09-23" @default.
- W56215835 title "[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer]." @default.
- W56215835 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21122380" @default.
- W56215835 hasPublicationYear "2010" @default.
- W56215835 type Work @default.
- W56215835 sameAs 56215835 @default.
- W56215835 citedByCount "6" @default.
- W56215835 countsByYear W562158352012 @default.
- W56215835 countsByYear W562158352014 @default.
- W56215835 countsByYear W562158352015 @default.
- W56215835 crossrefType "journal-article" @default.
- W56215835 hasAuthorship W56215835A5004324240 @default.
- W56215835 hasAuthorship W56215835A5009604094 @default.
- W56215835 hasAuthorship W56215835A5036726873 @default.
- W56215835 hasAuthorship W56215835A5043935779 @default.
- W56215835 hasAuthorship W56215835A5045422255 @default.
- W56215835 hasAuthorship W56215835A5050921331 @default.
- W56215835 hasAuthorship W56215835A5055687694 @default.
- W56215835 hasAuthorship W56215835A5081681814 @default.
- W56215835 hasConcept C104317684 @default.
- W56215835 hasConcept C121608353 @default.
- W56215835 hasConcept C126322002 @default.
- W56215835 hasConcept C143998085 @default.
- W56215835 hasConcept C2776256026 @default.
- W56215835 hasConcept C2778087573 @default.
- W56215835 hasConcept C2779438470 @default.
- W56215835 hasConcept C2909325608 @default.
- W56215835 hasConcept C2994225774 @default.
- W56215835 hasConcept C36823959 @default.
- W56215835 hasConcept C501734568 @default.
- W56215835 hasConcept C502942594 @default.
- W56215835 hasConcept C54355233 @default.
- W56215835 hasConcept C71924100 @default.
- W56215835 hasConcept C86803240 @default.
- W56215835 hasConceptScore W56215835C104317684 @default.
- W56215835 hasConceptScore W56215835C121608353 @default.
- W56215835 hasConceptScore W56215835C126322002 @default.
- W56215835 hasConceptScore W56215835C143998085 @default.
- W56215835 hasConceptScore W56215835C2776256026 @default.
- W56215835 hasConceptScore W56215835C2778087573 @default.
- W56215835 hasConceptScore W56215835C2779438470 @default.
- W56215835 hasConceptScore W56215835C2909325608 @default.
- W56215835 hasConceptScore W56215835C2994225774 @default.
- W56215835 hasConceptScore W56215835C36823959 @default.
- W56215835 hasConceptScore W56215835C501734568 @default.
- W56215835 hasConceptScore W56215835C502942594 @default.
- W56215835 hasConceptScore W56215835C54355233 @default.
- W56215835 hasConceptScore W56215835C71924100 @default.
- W56215835 hasConceptScore W56215835C86803240 @default.
- W56215835 hasIssue "9" @default.
- W56215835 hasLocation W562158351 @default.
- W56215835 hasOpenAccess W56215835 @default.
- W56215835 hasPrimaryLocation W562158351 @default.
- W56215835 hasRelatedWork W1503952583 @default.
- W56215835 hasRelatedWork W1506244879 @default.
- W56215835 hasRelatedWork W1517884348 @default.
- W56215835 hasRelatedWork W1968105231 @default.
- W56215835 hasRelatedWork W1998978533 @default.
- W56215835 hasRelatedWork W2051380611 @default.
- W56215835 hasRelatedWork W2058482597 @default.
- W56215835 hasRelatedWork W2312718420 @default.
- W56215835 hasRelatedWork W2350222111 @default.
- W56215835 hasRelatedWork W2351551998 @default.
- W56215835 hasRelatedWork W2380789503 @default.
- W56215835 hasRelatedWork W2386416168 @default.
- W56215835 hasRelatedWork W2413018677 @default.
- W56215835 hasRelatedWork W2567488321 @default.
- W56215835 hasRelatedWork W2899249979 @default.
- W56215835 hasRelatedWork W2900799599 @default.
- W56215835 hasRelatedWork W2906803916 @default.
- W56215835 hasRelatedWork W3014588444 @default.
- W56215835 hasRelatedWork W3032532168 @default.
- W56215835 hasRelatedWork W3161714993 @default.
- W56215835 hasVolume "32" @default.
- W56215835 isParatext "false" @default.
- W56215835 isRetracted "false" @default.
- W56215835 magId "56215835" @default.
- W56215835 workType "article" @default.