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• W562416231 endingPage "2227" @default.
• W562416231 startingPage "2217" @default.
• W562416231 abstract "Adaptability to stress is a fundamental prerequisite for survival. Mitochondria are a key component of the stress response in all cells. For steroid-hormones-producing cells, including also Leydig cells of testes, the mitochondria are a key control point for the steroid biosynthesis and regulation. However, the mitochondrial biogenesis in steroidogenic cells has never been explored. Here we show that increased mitochondrial biogenesis is the adaptive response of testosterone-producing Leydig cells from stressed rats. All markers of mitochondrial biogenesis together with transcription factors and related kinases are up-regulated in Leydig cells from rats exposed to repeated psychophysical stress. This is followed with increased mitochondrial mass. The expression of PGC1, master regulator of mitochondrial biogenesis and integrator of environmental signals, is stimulated by cAMP-PRKA, cGMP, and β-adrenergic receptors. Accordingly, stress-triggered mitochondrial biogenesis represents an adaptive mechanism and does not only correlate with but also is an essential for testosterone production, being both events depend on the same regulators. Here we propose that all events induced by acute stress, the most common stress in human society, provoke adaptive response of testosterone-producing Leydig cells and activate PGC1, a protein required to make new mitochondria but also protector against the oxidative damage. Given the importance of mitochondria for steroid hormones production and stress response, as well as the role of steroid hormones in stress response and metabolic syndrome, we anticipate our result to be a starting point for more investigations since stress is a constant factor in life and has become one of the most significant health problems in modern societies." @default.
• W562416231 created "2016-06-24" @default.
• W562416231 creator A5017891995 @default.
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• W562416231 creator A5069461123 @default.
• W562416231 creator A5087636929 @default.
• W562416231 creator A5091428600 @default.
• W562416231 date "2015-10-01" @default.
• W562416231 modified "2023-10-18" @default.
• W562416231 title "Stress triggers mitochondrial biogenesis to preserve steroidogenesis in Leydig cells" @default.
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• W562416231 doi "https://doi.org/10.1016/j.bbamcr.2015.05.030" @default.
• W562416231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26036344" @default.
• W562416231 hasPublicationYear "2015" @default.
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