Matches in SemOpenAlex for { <https://semopenalex.org/work/W562723169> ?p ?o ?g. }
- W562723169 endingPage "74" @default.
- W562723169 startingPage "68" @default.
- W562723169 abstract "Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs). However, the differentiation from OPCs to oligodendrocytes is disturbed under stressed conditions. Therefore, drugs that can improve oligodendrocyte regeneration may be effective for white matter-related diseases. Here we show that a vasoactive peptide adrenomedullin (AM) promotes the in vitro differentiation of OPCs under pathological conditions. Primary OPCs were prepared from neonatal rat brains, and differentiated into myelin-basic-protein expressing oligodendrocytes over time. This in vitro OPC differentiation was inhibited by prolonged chemical hypoxic stress induced by non-lethal CoCl(2) treatment. However, AM promoted the OPC differentiation under the hypoxic stress conditions, and the AM receptor antagonist AM(22-52) canceled the AM-induced OPC differentiation. In addition, AM treatment increased the phosphorylation level of Akt in OPC cultures, and correspondingly, the PI3K/Akt inhibitor LY294002 blocked the AM-induced OPC differentiation. Taken together, AM treatment rescued OPC maturation under pathological conditions via an AM-receptor-PI3K/Akt pathway. Oligodendrocytes play critical roles in white matter by forming myelin sheath. Therefore, AM signaling may be a promising therapeutic target to boost oligodendrocyte regeneration in CNS disorders." @default.
- W562723169 created "2016-06-24" @default.
- W562723169 creator A5009335165 @default.
- W562723169 creator A5019184835 @default.
- W562723169 creator A5035202189 @default.
- W562723169 creator A5062438568 @default.
- W562723169 creator A5066036251 @default.
- W562723169 creator A5089818160 @default.
- W562723169 creator A5091447153 @default.
- W562723169 date "2015-07-01" @default.
- W562723169 modified "2023-10-16" @default.
- W562723169 title "Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro" @default.
- W562723169 cites W104000955 @default.
- W562723169 cites W1494144074 @default.
- W562723169 cites W1965575731 @default.
- W562723169 cites W1966079920 @default.
- W562723169 cites W1981608894 @default.
- W562723169 cites W1990822074 @default.
- W562723169 cites W2000485285 @default.
- W562723169 cites W2001810970 @default.
- W562723169 cites W2006606792 @default.
- W562723169 cites W2022244667 @default.
- W562723169 cites W2025146799 @default.
- W562723169 cites W2042073008 @default.
- W562723169 cites W2043595907 @default.
- W562723169 cites W2045321639 @default.
- W562723169 cites W2047874606 @default.
- W562723169 cites W2048082433 @default.
- W562723169 cites W2050989030 @default.
- W562723169 cites W2056198120 @default.
- W562723169 cites W2065770359 @default.
- W562723169 cites W2068488670 @default.
- W562723169 cites W2085029391 @default.
- W562723169 cites W2088367417 @default.
- W562723169 cites W2089127919 @default.
- W562723169 cites W2092419989 @default.
- W562723169 cites W2092576179 @default.
- W562723169 cites W2092666843 @default.
- W562723169 cites W2093791199 @default.
- W562723169 cites W2095490681 @default.
- W562723169 cites W2099365888 @default.
- W562723169 cites W2104583114 @default.
- W562723169 cites W2111646407 @default.
- W562723169 cites W2111907475 @default.
- W562723169 cites W2120197600 @default.
- W562723169 cites W2125650861 @default.
- W562723169 cites W2126968890 @default.
- W562723169 cites W2128484122 @default.
- W562723169 cites W2133934222 @default.
- W562723169 cites W2145988432 @default.
- W562723169 cites W2146101679 @default.
- W562723169 cites W2147425081 @default.
- W562723169 cites W2148631338 @default.
- W562723169 cites W2150922547 @default.
- W562723169 cites W2152948578 @default.
- W562723169 cites W2153633999 @default.
- W562723169 cites W2162189519 @default.
- W562723169 cites W2162978741 @default.
- W562723169 cites W2172266463 @default.
- W562723169 doi "https://doi.org/10.1016/j.scr.2015.05.001" @default.
- W562723169 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4516627" @default.
- W562723169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26002630" @default.
- W562723169 hasPublicationYear "2015" @default.
- W562723169 type Work @default.
- W562723169 sameAs 562723169 @default.
- W562723169 citedByCount "26" @default.
- W562723169 countsByYear W5627231692016 @default.
- W562723169 countsByYear W5627231692017 @default.
- W562723169 countsByYear W5627231692018 @default.
- W562723169 countsByYear W5627231692019 @default.
- W562723169 countsByYear W5627231692020 @default.
- W562723169 countsByYear W5627231692021 @default.
- W562723169 countsByYear W5627231692022 @default.
- W562723169 countsByYear W5627231692023 @default.
- W562723169 crossrefType "journal-article" @default.
- W562723169 hasAuthorship W562723169A5009335165 @default.
- W562723169 hasAuthorship W562723169A5019184835 @default.
- W562723169 hasAuthorship W562723169A5035202189 @default.
- W562723169 hasAuthorship W562723169A5062438568 @default.
- W562723169 hasAuthorship W562723169A5066036251 @default.
- W562723169 hasAuthorship W562723169A5089818160 @default.
- W562723169 hasAuthorship W562723169A5091447153 @default.
- W562723169 hasBestOaLocation W5627231691 @default.
- W562723169 hasConcept C104317684 @default.
- W562723169 hasConcept C148738053 @default.
- W562723169 hasConcept C169760540 @default.
- W562723169 hasConcept C170493617 @default.
- W562723169 hasConcept C2776912716 @default.
- W562723169 hasConcept C2776985911 @default.
- W562723169 hasConcept C2777152744 @default.
- W562723169 hasConcept C2777619251 @default.
- W562723169 hasConcept C2778609137 @default.
- W562723169 hasConcept C2780876595 @default.
- W562723169 hasConcept C529278444 @default.
- W562723169 hasConcept C55493867 @default.
- W562723169 hasConcept C62478195 @default.
- W562723169 hasConcept C75217442 @default.
- W562723169 hasConcept C86554907 @default.