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- W56317130 abstract "The mobile elements responsible for capture and mobilization of resistance genes include composite transposons, characterized by insertion sequences on either side of a single gene or a small number of genes. Early examples were Tn5, Tn9, and Tn10, coding resistance to kanamycin + streptomycin, chloramphenicol, and tetracycline, respectively. Possibly any chromosomal resistance gene can become part of a composite transposon by receiving an insertion sequence on both sides. Simple or unit transposons, with only short repeats flanking the transposition genes, have also been efficient vehicles for resistance gene dissemination. Examples are Tn3 and relatives carrying a wide variety of extended-spectrum TEM-β-lactamases, and Tn1546 with its entire vancomycin resistance operon. Conjugative transposons are also important vectors of vancomycin resistance." @default.
- W56317130 created "2016-06-24" @default.
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- W56317130 date "2009-01-01" @default.
- W56317130 modified "2023-10-16" @default.
- W56317130 title "Genetic Mechanisms of Transfer of Drug Resistance" @default.
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- W56317130 doi "https://doi.org/10.1007/978-1-59745-180-2_5" @default.
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