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- W56462523 abstract "Calcium (Ca{sup ++})-induced clotting times (i.e., prothrombin times, PT times) in young White Leghorn chickens and male weanling Sprague Dawley rats were shown to be elevated in animals fed diets for 20-30 days containing excess Se. Clotting times of chicks were prolonged from those of controls in animals fed either deficient or excess Se, although all dietary treatment groups showed comparable concentrations of total plasma protein. Rats showed significantly prolonged PT times when fed Se at either 5 ppm or 10 ppm. The plasma activities of certain enzymes of hepatic origin (alanine aminotransferase, aspartate aminotransferase, {gamma}-glutamyl transpeptidase) in rats fed excess Se were comparable to those of controls, despite the increase in the PT times. Body weights and liver weights were significantly depressed in those animals only at the 10 ppm Se level. These results demonstrate increased PT times in both chicks and rats. In each species, this effect is independent of feed intake and body weight, and is apparent at levels of Se intake that do not affect other indicators of hepatic damage. Therefore, prolonged PT time may be an early indicator of sub-acute selenosis." @default.
- W56462523 created "2016-06-24" @default.
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- W56462523 date "1991-03-11" @default.
- W56462523 modified "2023-09-26" @default.
- W56462523 title "Excess selenium increases Ca sup ++ -induced clotting times in chicks and rats" @default.
- W56462523 hasPublicationYear "1991" @default.
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