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- W56554433 abstract "This chapter discusses a study to investigate the effect of trazodone and its metabolite, m-chlorophenylpiperazine (CPP), on acquisition of conditioned avoidance response. Male CD-1 mice were trained for conditioned avoidance response (CAR) in a shuttle-box apparatus. Each group consisted of 8 mice. The training comprised of 5 daily sessions of 100 trials each. CPP, 2 or 5 mg/kg (hydrochloride), was given 30 min before each session. Before CPP, the following drugs were given at times as indicated: cyproheptadine hydrochloride (CHD) 0.5 or 1 mg/kg, 30 min; alpha-methyl-p-tyrosine (AMT) 100 mg/kg, 90 min; pimozide (PMZ) 0.2 mg/kg, 60 min. All drugs were dissolved in 0.9% NaCl solution (saline), with the exception of PMZ, which was dissolved in 0.2% tartaric acid (vehicle). The controls received the solvent (10 ml/kg) at appropriate time intervals. All injections were given intraperitoneally. It was found that CHD did not antagonize the facilitatory action of CPP and in a dose of 1 mg/kg facilitated the CAR acquisition by itself. The effects of CPP and CHD were not additive." @default.
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- W56554433 date "1986-01-01" @default.
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- W56554433 title "The Effect of Trazodone and Its Metabolite, CPP, on Acquisition of Conditioned Avoidance Response" @default.
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- W56554433 doi "https://doi.org/10.1016/b978-0-08-034186-6.50072-4" @default.
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