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- W565548377 abstract "Objective: Zoonotic pathogens account for more than 60% of all infections known to cause human diseases, of which bacteria represent more than one third of all zoonoses. Furthermore, most zoonoses are shared between closely related species with overlapping geographical ranges. Therefore, humans are likely to be at a high risk of contracting zoonoses from other great apes and vice versa. The orangutans (Pongo sp.) of Borneo and Sumatra are the only great apes that are found outside of Africa, known for their unique ecological adaptations, close evolutionary relationship and occasional contact with humans, and their threat of extinction due to habitat destruction and hunting. We conducted a pilot study to test for the potential occurrence and prevalence of human pathogenic Staphylococcus and Streptococcus species in wild orangutans.Methods: DNA was isolated from non-invasively collected feacal samples from wild habituated Bornean and Sumatran orangutans. DNA-isolates were selected based on previous 454-sequencing results [unpublished] indicating the presence ofStaphylococcusandStreptococcusspecies. These samples were screened and sequenced with PCR using genus specific Staphylococcus (tuf gene) and Streptococcus (rnpB gene) primers. All sequences were aligned with published type sequences using MAFFT. Phylogenetic analysis was conducted using Bayesian analyses with MrBayes.Results: Of the 15 faecal samples screened for Staphylococcus spp., five were successfully sequenced. One sequence indicated close relationship with otherS. saprophyticussequences. Two sequences indicated close relationship withS. cohnii ssp. urealyticus, and one clustered with S. arlettae sequences. Of the 25 faecal samples screened for Streptococcus spp., thirteen were successfully sequenced. Ten sequences were indicated to be related toS. gallolyticustype sequences. Three sequences did not cluster with any of the published Streptococcus type sequences.Conclusions:We identified three known human pathogenic bacteria indicated to be present in wild orangutans:Staphylococcus saprophyticusis a common cause of urinary tract infections in women.Staphylococcus cohnii subsp. urealyticus has been implicated to be the cause of bacteremia following community-acquired skin infections. Streptococcus gallolyticus has a strong association with the development of colorectal cancer and endocarditis. Further research is necessary to demonstrate if the orangutans acquired these bacterial infections from human sources and if these infections are pathogenic to orangutans." @default.
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- W565548377 date "2013-01-01" @default.
- W565548377 modified "2023-09-27" @default.
- W565548377 title "Staphylococcal and Streptococcal zoonoses in wild Bornean and Sumatran orangutans" @default.
- W565548377 hasPublicationYear "2013" @default.
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