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- W56555044 abstract "Mesenchymal stem cells (MSCs) are multipotent cells and exhibit two main characteristics that define stem cells: self-renewal and differentiation. MSCs can migrate to sites of injury, inflammation, and tumor. Moreover, MSCs undergo myofibroblast-like differentiation, including increased production of alpha smooth muscle actin (α-SMA) in response to transforming growth factor-β (TGF-β), a growth factor commonly secreted by tumor cells to evade immune surveillance. Based on our previous finding, hMSCs become activated and resemble carcinoma-associated myofibroblasts upon prolonged exposure to conditioned medium from MDAMB231 human breast cancer cells. Here, we show that keratinocyte-conditioned medium (KCM) induces differentiation of MSCs to resemble dermal myofibroblast-like cells using immunofluorescence techniques demonstrating punctate vinculin staining, and F-actin filaments." @default.
- W56555044 created "2016-06-24" @default.
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- W56555044 date "2011-01-01" @default.
- W56555044 modified "2023-10-05" @default.
- W56555044 title "Activation and Differentiation of Mesenchymal Stem Cells" @default.
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- W56555044 doi "https://doi.org/10.1007/978-1-61779-024-9_14" @default.
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