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- W56557976 abstract "Mammals maintain energy homeostasis by regulating sympathetic nervous system. We previously reported that GPR41, a Gi/o-protein coupled receptor for short-chain fatty acids (SCFAs), directly regulate sympathetic activity and energy expenditure at the level of ganglion (1). However, the signaling mechanism for GPR41-mediated sympathetic activation in details remains to be elucidated. In this study, we examined the downstream signaling of GPR41 for sympathetic activation using primary-cultured mouse sympathetic neurons. SCFA propionate increased tritium-labeled noradrenaline secretion via GPR41. Pharmacological and RNAi experiments showed that propionate-induced increase of noradrenaline secretion is mediated by Gβγ-PLCβ3-ERK1/2 pathway. Moreover, co-immunoprecipitation experiments showed that activated ERK1/2 phosphorylates synapsin2, synaptic vesicle-associated protein. Furthermore, siRNA for synapsin2 effectively suppressed propionate-induced noradrenaline secretion. The results show a novel signaling mechanism for Gai/o-coupled receptor GPR41-promoted noradrenaline secretion from sympathetic nerve. This study was supported by research grants from the Japan Science and Technology Agency." @default.
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- W56557976 date "2012-04-01" @default.
- W56557976 modified "2023-09-27" @default.
- W56557976 title "Short‐chain fatty acids activate sympathetic neurons via a novel signaling pathway" @default.
- W56557976 doi "https://doi.org/10.1096/fasebj.26.1_supplement.762.3" @default.
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