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- W565599071 abstract "To investigate the protective effect of Total Flavonids of Epimedium (TFE) on D-galactose-induced H9c2 cells senescence and to explore the underlying mechanisms.D-galactosed (50 mmol/L) were used to induce the aging of H9c2 cells. Different concentrations of TFE (5,25 and 50 µg/mL) were added into the medium before the use of D-galactosed. Cells senescence was identified by β-galactosidase and the changes in cell morphology were observed. The activity of superoxide dismutase(SOD) and the content of malondial dehyde (MDA) were measured. Reactive oxygen species( ROS) was observed by DCFH-DA detection and the apoptosis was tested by Hochest.In the D-gal group,the number of β-galactosidase-positive cells, the content of MDA and the fluorescence intensity of ROS were markedly increased. In the meanwhile,the chromatin was condensated and the apoptotic bodies were seen by using Hochest. Compared with the D-gal group, TFE apparently decreased the quantity of β-galactosidase-positive cells, the content of MDA, and the florescence intensity of ROS, increased the activity of SOD, and enhanced the condition of chromatin.TFE can confront D-galactose-induced senescence in H9c2 cells by increasing the ability of antioxidant and reducing the number of apoptosis." @default.
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- W565599071 date "2014-12-01" @default.
- W565599071 modified "2023-09-25" @default.
- W565599071 title "[Protective Effect of Total Flavonoids of Epimedium on D-galactose-induced Senescence in H9c2 Cells]." @default.
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