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- W56572246 abstract "The transfer of anti-allotype (anti Ig-l b ) antibodies from immune Balb/c mothers to their Balb/c offspring has been studied using a combination of isoelectric focussing and autoradiography. The results show a selective transmission of maternal antibody which appears to favour immunoglobulin molecules of lower pI., the selection operating at the level of the neonatal gut. A development of this technique was then used to investigate the production of the Ig-1 b allotype in both normal and experimentally suppressed Balb/cxSJL F1 mice. The generation of Ig-1 b in normal Balb/cxSJL controls occurs around day 40 with the production of polyclonal Ig-1 b , but in some experimentally suppressed animals there is a clear restriction of spectrotype which favours Ig-1 b of lower pI. This contrasts with other experimental animals which show a polyclonal “on–off” synthesis of the allotype." @default.
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- W56572246 date "1981-01-01" @default.
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- W56572246 title "CLONAL HETEROGENEITY OF ANTIBODIES IN THE NEWBORN MOUSE—AN APPROACH TO THE PROBLEM OF THE GENERATION OF DIVERSITY" @default.
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- W56572246 doi "https://doi.org/10.1016/b978-0-08-025922-2.50013-9" @default.
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