Matches in SemOpenAlex for { <https://semopenalex.org/work/W565760106> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W565760106 abstract "Arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase) is the lysosomal and membrane enzyme that removes 4-sulfate groups from the non-reducing end of chondroitin 4-sulfate and dermatan sulfate, and thereby regulates their degradation. Studies have demonstrated decline in ARSB in patients with cystic fibrosis and in malignant human mammary, prostate, and colonic epithelial tissues. Several molecules, including Interleukin-8, high molecular weight kininogen, BMP4, and galectin-3, bind preferentially to more or less sulfated C4S, affecting cell-cell and cell-extracellular matrix interactions. Previously, we reported that hypoxia reduced ARSB activity and that decline in ARSB replicated the effects of hypoxia on the expression of 84 genes in a hypoxia gene array. Both hypoxia and silencing ARSB decreased the ratios of reduced glutathione to GSSG and of cellular sulfhydryls to sulfides. Recent experiments in ARSB-deficient mice and human epithelial cells following ARSB silencing have shown: increased serum lactate, increased 2,3-DPG, increased extracellular acidfication, reduced oxygen consumption rate, reduced mitochondrial membrane potential, disruption of inner and outer mitochondrial membranes by electron microscopy, and increased NADPH to NADP and NADH to NAD ratios. These findings suggest profound effects of decline in ARSB on cellular metabolism and oxidation-reduction reactions. Sulfate reduction is utilized in protists, plants, and algae for energy production. Impairment of sulfate reduction due to unavailability of sulfate due to ARSB deficiency may help to explain the occurrence of aerobic glycolysis in human cells." @default.
- W565760106 created "2016-06-24" @default.
- W565760106 creator A5050602618 @default.
- W565760106 creator A5052370440 @default.
- W565760106 creator A5063815487 @default.
- W565760106 date "2015-04-01" @default.
- W565760106 modified "2023-09-26" @default.
- W565760106 title "Defining the Role of Arylsulfatase B (N‐Acetylgalactosamine 4‐Sulfatase) in Cellular Metabolism" @default.
- W565760106 doi "https://doi.org/10.1096/fasebj.29.1_supplement.725.16" @default.
- W565760106 hasPublicationYear "2015" @default.
- W565760106 type Work @default.
- W565760106 sameAs 565760106 @default.
- W565760106 citedByCount "1" @default.
- W565760106 countsByYear W5657601062019 @default.
- W565760106 crossrefType "journal-article" @default.
- W565760106 hasAuthorship W565760106A5050602618 @default.
- W565760106 hasAuthorship W565760106A5052370440 @default.
- W565760106 hasAuthorship W565760106A5063815487 @default.
- W565760106 hasConcept C185592680 @default.
- W565760106 hasConcept C20251656 @default.
- W565760106 hasConcept C55493867 @default.
- W565760106 hasConcept C62231903 @default.
- W565760106 hasConcept C86803240 @default.
- W565760106 hasConcept C95444343 @default.
- W565760106 hasConceptScore W565760106C185592680 @default.
- W565760106 hasConceptScore W565760106C20251656 @default.
- W565760106 hasConceptScore W565760106C55493867 @default.
- W565760106 hasConceptScore W565760106C62231903 @default.
- W565760106 hasConceptScore W565760106C86803240 @default.
- W565760106 hasConceptScore W565760106C95444343 @default.
- W565760106 hasIssue "S1" @default.
- W565760106 hasLocation W5657601061 @default.
- W565760106 hasOpenAccess W565760106 @default.
- W565760106 hasPrimaryLocation W5657601061 @default.
- W565760106 hasRelatedWork W1547091325 @default.
- W565760106 hasRelatedWork W196478107 @default.
- W565760106 hasRelatedWork W1979838084 @default.
- W565760106 hasRelatedWork W2008102720 @default.
- W565760106 hasRelatedWork W2013713538 @default.
- W565760106 hasRelatedWork W2086949087 @default.
- W565760106 hasRelatedWork W2090825710 @default.
- W565760106 hasRelatedWork W2106928991 @default.
- W565760106 hasRelatedWork W2911900491 @default.
- W565760106 hasRelatedWork W3094724625 @default.
- W565760106 hasVolume "29" @default.
- W565760106 isParatext "false" @default.
- W565760106 isRetracted "false" @default.
- W565760106 magId "565760106" @default.
- W565760106 workType "article" @default.