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• W565760154 abstract "Numerous studies in experimental animals have emphasized the importance of tachykinin peptides in hypothalamic function. There is however, little information on the location of these peptides in the himian brain. In the first study, in situ hybridization was used to map the distribution of neurons expressing the substance P (SP) or neurokinin B (NKB) gene transcripts. The distribution of neurons containing tachykinin mRNAs was found to be distinct and complementary: SP was the predominant tachykinin in the striatum, posterior hypothalamus and intermediate, ventromedial and mammillary nuclei; there were more NKB mRNA containing neurons than SP neurons in the magnocellular basal forebrain, the bed nucleus, and the preoptic/anterior h>'pothalamic regions. Comparable numbers of neurons expressing both mRNAs were identified in the infundibular nucleus and amygdala. Because numerous neurons containing NKB mRNAs were identified in the nucleus basalis of Meynert, it was next determined if NKB mRNA and choline acetyltransferase (ChAT) mRNAs are colocalized in this region. It was found that approximately 30% of the cholinergic neurons in the nucleus basalis also expressed NKB gene transcripts. This is the first identification of peptide colocalization in a significant population of magnocellular cholinergic neurons in the human basal forebrain. The nucleus basalis of Meynert plays an important role in higher brain fimctions in humans. There is considerable evidence suggesting that SP and gonadotropin releasing hormone (GnRH) neurons are anatomically and functionally connected in the human brain. In this study, double in situ hybridization with ^^S-labeled SP receptor (SPR) and digoxigenin-labeled GnRH riboprobes was used to determine if GnRH neurons contain" @default.
• W565760154 created "2016-06-24" @default.
• W565760154 creator A5091305201 @default.
• W565760154 date "1996-01-01" @default.
• W565760154 modified "2023-09-24" @default.
• W565760154 title "Localization of tachykinins and their receptormRNAs in the human hypothalamus and basal forebrain" @default.
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