FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W566758538> ?p ?o ?g. }

• W566758538 endingPage "6591" @default.
• W566758538 startingPage "6591" @default.
• W566758538 abstract "To investigate the continuous hepatic histopathological processes which occur in response to the loss of Dicer1.We generated a hepatocyte-selective Dicer1 knockout mouse and observed the gradual hepatic histopathological changes in the mutant liver. Immunohistochemistry and Western blotting were performed to detect Dicer1 expression. We performed hematoxylin and eosin staining, Periodic acid-Schiff staining, Oil Red O staining, and Masson's trichrome staining to detect histological changes in Dicer1-deficient livers. Ki67 immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay, and Western blotting were used to determine hepatocyte proliferation and apoptosis. Serum biochemistry, cytokine assays, and flow cytometric analysis were performed to quantity liver necrosis and inflammation. Fibrogenic markers were determined by Western blotting and qPCR. CK19, CD133, and OV6 immunofluorescence were used to observe liver progenitor cells. Immunofluorescence and qPCR were performed to reveal embryonic gene expression. We also performed histological staining and Western blotting to analyze hepatocellular carcinoma (HCC) development.Dicer1 inactivation resulted in significant architecture disorganization and metabolism disruption in the liver. Dicer1 disruption impaired hepatocyte survival and resulted in profound cell apoptosis and continuous necrosis. In contrast to previous reports, the mutant liver exhibited chronic inflammation and progressive fibrosis, and could not be repopulated by Dicer1-positive cells. In addition, extensive activation of hepatic progenitor cells was observed. Primary HCC was observed as early as 4 mo after birth.Hepatic loss of Dicer1 results in complex chronic pathological processes, including hepatocyte death, inflammatory infiltration, chronic fibrosis, compensatory proliferation, progenitor activation, and spontaneous hepatocarcinogenesis." @default.
• W566758538 created "2016-06-24" @default.
• W566758538 creator A5039420953 @default.
• W566758538 date "2015-01-01" @default.
• W566758538 modified "2023-09-25" @default.
• W566758538 title "Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation" @default.
• W566758538 cites W144423133 @default.
• W566758538 cites W1483496013 @default.
• W566758538 cites W1648301895 @default.
• W566758538 cites W1923716760 @default.
• W566758538 cites W1964631913 @default.
• W566758538 cites W1967467247 @default.
• W566758538 cites W1973278012 @default.
• W566758538 cites W1987315409 @default.
• W566758538 cites W1998404710 @default.
• W566758538 cites W2002995168 @default.
• W566758538 cites W2004266769 @default.
• W566758538 cites W2004576498 @default.
• W566758538 cites W2021256244 @default.
• W566758538 cites W2022687771 @default.
• W566758538 cites W2026531690 @default.
• W566758538 cites W2029426792 @default.
• W566758538 cites W2030166934 @default.
• W566758538 cites W2043058521 @default.
• W566758538 cites W2053490054 @default.
• W566758538 cites W2059357290 @default.
• W566758538 cites W2063653640 @default.
• W566758538 cites W2068847708 @default.
• W566758538 cites W2070549269 @default.
• W566758538 cites W2077475358 @default.
• W566758538 cites W2080998956 @default.
• W566758538 cites W2082381304 @default.
• W566758538 cites W2083274861 @default.
• W566758538 cites W2089154676 @default.
• W566758538 cites W2100932663 @default.
• W566758538 cites W2105679485 @default.
• W566758538 cites W2114202720 @default.
• W566758538 cites W2122522101 @default.
• W566758538 cites W2128459167 @default.
• W566758538 cites W2128674168 @default.
• W566758538 cites W2137257146 @default.
• W566758538 cites W2139342290 @default.
• W566758538 cites W2140116051 @default.
• W566758538 cites W2146385212 @default.
• W566758538 cites W2159807040 @default.
• W566758538 cites W2162674813 @default.
• W566758538 cites W2162807448 @default.
• W566758538 cites W2597632520 @default.
• W566758538 doi "https://doi.org/10.3748/wjg.v21.i21.6591" @default.
• W566758538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4458769" @default.
• W566758538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26074697" @default.
• W566758538 hasPublicationYear "2015" @default.
• W566758538 type Work @default.
• W566758538 sameAs 566758538 @default.
• W566758538 citedByCount "8" @default.
• W566758538 countsByYear W5667585382016 @default.
• W566758538 countsByYear W5667585382017 @default.
• W566758538 countsByYear W5667585382019 @default.
• W566758538 countsByYear W5667585382022 @default.
• W566758538 countsByYear W5667585382023 @default.
• W566758538 crossrefType "journal-article" @default.
• W566758538 hasAuthorship W566758538A5039420953 @default.
• W566758538 hasBestOaLocation W5667585381 @default.
• W566758538 hasConcept C104317684 @default.
• W566758538 hasConcept C134018914 @default.
• W566758538 hasConcept C142724271 @default.
• W566758538 hasConcept C153911025 @default.
• W566758538 hasConcept C176891718 @default.
• W566758538 hasConcept C201750760 @default.
• W566758538 hasConcept C202751555 @default.
• W566758538 hasConcept C203014093 @default.
• W566758538 hasConcept C2776200302 @default.
• W566758538 hasConcept C2776637226 @default.
• W566758538 hasConcept C2776914184 @default.
• W566758538 hasConcept C2780559512 @default.
• W566758538 hasConcept C28328180 @default.
• W566758538 hasConcept C502942594 @default.
• W566758538 hasConcept C55493867 @default.
• W566758538 hasConcept C71924100 @default.
• W566758538 hasConcept C85265743 @default.
• W566758538 hasConcept C86803240 @default.
• W566758538 hasConcept C95444343 @default.
• W566758538 hasConceptScore W566758538C104317684 @default.
• W566758538 hasConceptScore W566758538C134018914 @default.
• W566758538 hasConceptScore W566758538C142724271 @default.
• W566758538 hasConceptScore W566758538C153911025 @default.
• W566758538 hasConceptScore W566758538C176891718 @default.
• W566758538 hasConceptScore W566758538C201750760 @default.
• W566758538 hasConceptScore W566758538C202751555 @default.
• W566758538 hasConceptScore W566758538C203014093 @default.
• W566758538 hasConceptScore W566758538C2776200302 @default.
• W566758538 hasConceptScore W566758538C2776637226 @default.
• W566758538 hasConceptScore W566758538C2776914184 @default.
• W566758538 hasConceptScore W566758538C2780559512 @default.
• W566758538 hasConceptScore W566758538C28328180 @default.
• W566758538 hasConceptScore W566758538C502942594 @default.
• W566758538 hasConceptScore W566758538C55493867 @default.
• W566758538 hasConceptScore W566758538C71924100 @default.

• next