Matches in SemOpenAlex for { <https://semopenalex.org/work/W56715622> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W56715622 abstract "Angiotensin (Ang) II exerts major influences on the heart and blood vessels via its effects on systemic hemodynamics and blood volume as well as structural effects. The major cardiovascular actions of Ang II have been reported to be mediated by the type 1 Ang II receptor or AT1 receptor. Recently, we have cloned a second receptor subtype known as AT2 receptor. The existence and differential expression of two different subtypes of Ang II receptors in the human myocardium and the reciprocal expression of AT1 and AT2 receptor in myocardial infarction and cardiac failure suggest pathophysiological importance of these receptors in cardiovascular disease and remodeling. Moreover, documented evidences suggest that the cellular composition of the heart and blood vessels is determined by the balance between apoptotic cell death (programmed cell death) and cell survival, and the unbalanced cell death plays a critical role in the pathogenesis of cardiovascular diseases and remodeling. Our successful clonings of AT2 receptor cDNAs have provided a unique opportunity to study the biology and function of this receptor. Indeed, in our previous experiments, we have demonstrated that AT2 receptor activates tyrosine phosphatase(s) and inhibits mitogen-activated protein kinase (MAPK) activation, thereby exerting the proapoptotic and antigrowth effects in several cells including cardiomyocytes and vascular smooth muscle cells. These antagonistic actions may contribute to the pathogenesis of cardiovascular diseases and remodeling." @default.
- W56715622 created "2016-06-24" @default.
- W56715622 creator A5001563356 @default.
- W56715622 creator A5068361428 @default.
- W56715622 creator A5086220632 @default.
- W56715622 creator A5090663343 @default.
- W56715622 date "1998-01-01" @default.
- W56715622 modified "2023-09-27" @default.
- W56715622 title "Angiotensin II Regulated Apoptosis in Cardiovascular Remodeling" @default.
- W56715622 cites W1967561584 @default.
- W56715622 cites W1968874083 @default.
- W56715622 cites W1974279158 @default.
- W56715622 cites W1976385326 @default.
- W56715622 cites W1990257506 @default.
- W56715622 cites W1990761820 @default.
- W56715622 cites W1997932090 @default.
- W56715622 cites W2007244655 @default.
- W56715622 cites W2010031713 @default.
- W56715622 cites W2017800047 @default.
- W56715622 cites W2031647568 @default.
- W56715622 cites W2037154107 @default.
- W56715622 cites W2052910631 @default.
- W56715622 cites W2054114699 @default.
- W56715622 cites W2055932468 @default.
- W56715622 cites W2060681074 @default.
- W56715622 cites W2076761806 @default.
- W56715622 cites W2077082072 @default.
- W56715622 cites W2077548365 @default.
- W56715622 cites W2082542825 @default.
- W56715622 cites W2092171289 @default.
- W56715622 cites W2095364526 @default.
- W56715622 cites W2106070854 @default.
- W56715622 cites W2111175065 @default.
- W56715622 cites W2131033837 @default.
- W56715622 cites W2142596758 @default.
- W56715622 cites W2149060182 @default.
- W56715622 cites W2980486406 @default.
- W56715622 doi "https://doi.org/10.1007/978-1-4615-5743-2_31" @default.
- W56715622 hasPublicationYear "1998" @default.
- W56715622 type Work @default.
- W56715622 sameAs 56715622 @default.
- W56715622 citedByCount "0" @default.
- W56715622 crossrefType "book-chapter" @default.
- W56715622 hasAuthorship W56715622A5001563356 @default.
- W56715622 hasAuthorship W56715622A5068361428 @default.
- W56715622 hasAuthorship W56715622A5086220632 @default.
- W56715622 hasAuthorship W56715622A5090663343 @default.
- W56715622 hasConcept C123915805 @default.
- W56715622 hasConcept C126322002 @default.
- W56715622 hasConcept C134018914 @default.
- W56715622 hasConcept C170493617 @default.
- W56715622 hasConcept C203014093 @default.
- W56715622 hasConcept C2778198053 @default.
- W56715622 hasConcept C2780942790 @default.
- W56715622 hasConcept C2908929049 @default.
- W56715622 hasConcept C62478195 @default.
- W56715622 hasConcept C71924100 @default.
- W56715622 hasConcept C86803240 @default.
- W56715622 hasConcept C95444343 @default.
- W56715622 hasConceptScore W56715622C123915805 @default.
- W56715622 hasConceptScore W56715622C126322002 @default.
- W56715622 hasConceptScore W56715622C134018914 @default.
- W56715622 hasConceptScore W56715622C170493617 @default.
- W56715622 hasConceptScore W56715622C203014093 @default.
- W56715622 hasConceptScore W56715622C2778198053 @default.
- W56715622 hasConceptScore W56715622C2780942790 @default.
- W56715622 hasConceptScore W56715622C2908929049 @default.
- W56715622 hasConceptScore W56715622C62478195 @default.
- W56715622 hasConceptScore W56715622C71924100 @default.
- W56715622 hasConceptScore W56715622C86803240 @default.
- W56715622 hasConceptScore W56715622C95444343 @default.
- W56715622 hasLocation W567156221 @default.
- W56715622 hasOpenAccess W56715622 @default.
- W56715622 hasPrimaryLocation W567156221 @default.
- W56715622 hasRelatedWork W123125161 @default.
- W56715622 hasRelatedWork W2014690611 @default.
- W56715622 hasRelatedWork W2018119516 @default.
- W56715622 hasRelatedWork W2047521555 @default.
- W56715622 hasRelatedWork W2051943841 @default.
- W56715622 hasRelatedWork W2098725621 @default.
- W56715622 hasRelatedWork W2144030911 @default.
- W56715622 hasRelatedWork W2149426387 @default.
- W56715622 hasRelatedWork W2156835140 @default.
- W56715622 hasRelatedWork W2169591410 @default.
- W56715622 hasRelatedWork W2326186332 @default.
- W56715622 hasRelatedWork W2405478420 @default.
- W56715622 hasRelatedWork W2410825127 @default.
- W56715622 hasRelatedWork W2416321936 @default.
- W56715622 hasRelatedWork W2465510895 @default.
- W56715622 hasRelatedWork W2466701431 @default.
- W56715622 hasRelatedWork W2990030343 @default.
- W56715622 hasRelatedWork W41763297 @default.
- W56715622 hasRelatedWork W56955019 @default.
- W56715622 hasRelatedWork W9532800 @default.
- W56715622 isParatext "false" @default.
- W56715622 isRetracted "false" @default.
- W56715622 magId "56715622" @default.
- W56715622 workType "book-chapter" @default.