Matches in SemOpenAlex for { <https://semopenalex.org/work/W56716713> ?p ?o ?g. }
- W56716713 endingPage "187" @default.
- W56716713 startingPage "167" @default.
- W56716713 abstract "Aminoacyl-tRNA synthetases (AARSs) are a group of essential and ubiquitous “house-keeping” enzymes responsible for charging corresponding amino acids to their cognate transfer RNAs (tRNAs) and providing the correct substrates for high-fidelity protein synthesis. During the last three decades, wide-ranging biochemical and genetic studies have revealed non-catalytic regulatory functions of multiple AARSs in biological processes including gene transcription, mRNA translation, and mitochondrial RNA splicing, and in diverse species from bacteria through yeasts to vertebrates. Remarkably, ongoing exploration of non-canonical functions of AARSs has shown that they contribute importantly to control of inflammation, angiogenesis, immune response, and tumorigenesis, among other critical physiopathological processes. In this chapter we consider the non-canonical functions of AARSs in regulating gene expression by mechanisms not directly related to their enzymatic activities, namely, at the levels of mRNA production, processing, and translation. The scope of AARS-mediated gene regulation ranges from negative autoregulation of single AARS genes to gene-selective control, and ultimately to global gene regulation. Clearly, AARSs have evolved these auxiliary regulatory functions that optimize the survival and well-being of the organism, possibly with more complex regulatory mechanisms associated with more complex organisms. In the first section on transcriptional control, we introduce the roles of autoregulation by Escherichia coli AlaRS, transcriptional activation by human LysRS, and transcriptional inhibition by vertebrate SerRS. In the second section on translational control, we recapitulate the roles of GluProRS in translation repression at the initiation step, auto-inhibition of E. coli thrS mRNA translation by ThrRS, and global translational arrest by phosphorylated human MetRS. Finally, in the third section, we describe the RNA splicing activities of mitochondrial TyrRS and LeuRS in Neurospora and yeasts, respectively." @default.
- W56716713 created "2016-06-24" @default.
- W56716713 creator A5004754997 @default.
- W56716713 creator A5030728909 @default.
- W56716713 creator A5047422822 @default.
- W56716713 creator A5086615981 @default.
- W56716713 date "2013-01-01" @default.
- W56716713 modified "2023-10-16" @default.
- W56716713 title "Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases" @default.
- W56716713 cites W127664203 @default.
- W56716713 cites W1491183859 @default.
- W56716713 cites W1579920465 @default.
- W56716713 cites W1604395293 @default.
- W56716713 cites W1672497183 @default.
- W56716713 cites W168371994 @default.
- W56716713 cites W1922219858 @default.
- W56716713 cites W1958214866 @default.
- W56716713 cites W1965106723 @default.
- W56716713 cites W1966985603 @default.
- W56716713 cites W1969115200 @default.
- W56716713 cites W1970790640 @default.
- W56716713 cites W1972101882 @default.
- W56716713 cites W1975924215 @default.
- W56716713 cites W1976616659 @default.
- W56716713 cites W1976701350 @default.
- W56716713 cites W1977213039 @default.
- W56716713 cites W1977329434 @default.
- W56716713 cites W1978035834 @default.
- W56716713 cites W1979502236 @default.
- W56716713 cites W1980205380 @default.
- W56716713 cites W1981529363 @default.
- W56716713 cites W1981710866 @default.
- W56716713 cites W1983463676 @default.
- W56716713 cites W1984274523 @default.
- W56716713 cites W1984560514 @default.
- W56716713 cites W1985892681 @default.
- W56716713 cites W1990794432 @default.
- W56716713 cites W1991213785 @default.
- W56716713 cites W1998848584 @default.
- W56716713 cites W1999253552 @default.
- W56716713 cites W1999921207 @default.
- W56716713 cites W2000371206 @default.
- W56716713 cites W2003012232 @default.
- W56716713 cites W2003052075 @default.
- W56716713 cites W2008264319 @default.
- W56716713 cites W2014077602 @default.
- W56716713 cites W2016336073 @default.
- W56716713 cites W2016733711 @default.
- W56716713 cites W2020085353 @default.
- W56716713 cites W2023298189 @default.
- W56716713 cites W2026234586 @default.
- W56716713 cites W2027247170 @default.
- W56716713 cites W2027533313 @default.
- W56716713 cites W2031683371 @default.
- W56716713 cites W2032464327 @default.
- W56716713 cites W2033784438 @default.
- W56716713 cites W2035728389 @default.
- W56716713 cites W2037295110 @default.
- W56716713 cites W2040223620 @default.
- W56716713 cites W2041406193 @default.
- W56716713 cites W2045445805 @default.
- W56716713 cites W2050804229 @default.
- W56716713 cites W2052676309 @default.
- W56716713 cites W2054476843 @default.
- W56716713 cites W2056400258 @default.
- W56716713 cites W2057032865 @default.
- W56716713 cites W2057481603 @default.
- W56716713 cites W2058414656 @default.
- W56716713 cites W2062347390 @default.
- W56716713 cites W2062862623 @default.
- W56716713 cites W2064494727 @default.
- W56716713 cites W2067886345 @default.
- W56716713 cites W2069520595 @default.
- W56716713 cites W2069564138 @default.
- W56716713 cites W2069689608 @default.
- W56716713 cites W2075992919 @default.
- W56716713 cites W2077432477 @default.
- W56716713 cites W2077510222 @default.
- W56716713 cites W2077514275 @default.
- W56716713 cites W2081981294 @default.
- W56716713 cites W2083591638 @default.
- W56716713 cites W2084160876 @default.
- W56716713 cites W2085567963 @default.
- W56716713 cites W2088246977 @default.
- W56716713 cites W2089170141 @default.
- W56716713 cites W2090015965 @default.
- W56716713 cites W2091313066 @default.
- W56716713 cites W2093558330 @default.
- W56716713 cites W2093994257 @default.
- W56716713 cites W2095224668 @default.
- W56716713 cites W2095250665 @default.
- W56716713 cites W2098918246 @default.
- W56716713 cites W2100534662 @default.
- W56716713 cites W2106179888 @default.
- W56716713 cites W2108431362 @default.
- W56716713 cites W2114972602 @default.
- W56716713 cites W2119507985 @default.
- W56716713 cites W2120843102 @default.