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- W56720679 abstract "Notch signaling is a highly conserved cell communication system that regulates a wide variety of cell types and cellular processes and as such plays a prominent role in the formation and function of the nervous system. Defects in Notch signaling have been implicated in a number of human disease states, including cancer, stroke, and Alzheimer’s disease, underscoring the importance of understanding the basic mechanisms of Notch signal transduction. Activation of Notch signaling involves regulated intramembrane proteolysis to effect release of the Notch intracellular domain, which serves to convert the Notch receptor into a downstream signal transducer. This seemingly simple signaling pathway is highly regulated at multiple steps and involves many different mechanisms that fine-tune the polarity, intensity, and duration of signaling." @default.
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- W56720679 date "2009-01-01" @default.
- W56720679 modified "2023-09-23" @default.
- W56720679 title "Notch Signal Transduction: Molecular and Cellular Mechanisms" @default.
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- W56720679 doi "https://doi.org/10.1016/b978-008045046-9.01026-3" @default.
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