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- W567687002 abstract "Tissue engineering is a promising therapeutic approach that assembles cells, biomaterials, and micro-environmental factors to promote tissue repair and functional restoration. Despite many advances, tissue engineers still face significant challenges in developing artifacts to promote dermal cell growth. Scaffolds are porous artifacts that serve as extracellular matrix but are able to create the microenvironment for the growth and differentiation of skin cells and enhanced tissue development. The emerging and promising next generation of engineered tissues is relying on producing biopolymeric scaffolds containing entities like growth factors, zeolites, mesoporous silica etc. , that promote enhanced skin regeneration. The use of zeolites has been considered as a way to manipulate the host healing response at the site of injury to facilitate the tissue repair. Moreover, natural polymers accomplish a diverse set of functions in their native setting. The modern trend is to mimic extracellular matrix and the most appropriate way is to choose natural polymers which are biocompatible, biodegradable and non-toxic. The current study is the evaluation of the potential of using zeolites embedded tissue engineering scaffolds based on natural polymers for wound healing applications. We have tried to excavate the wound healing properties of different faujasites incorporated tissue engineering scaffolds using biopolymers like pectin, carboxymethyl cellulose, gelatin and hyaluronic acid by techniques like lyophilisation and solvent casting. The structural, mechanical, thermal, water uptake and in vitro degradation studies of the prepared composite scaffolds were investigated. The antibacterial activity, cytotoxicity and wound healing studies on Sprague Dawley rats were discussed in detail which state that zeolites incorporated scaffolds are suitable candidates for wound dressing." @default.
- W567687002 created "2016-06-24" @default.
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- W567687002 date "2013-01-01" @default.
- W567687002 modified "2023-09-23" @default.
- W567687002 title "Synthesis, characterisation and biological evaluation of tissue engineering scaffolds for wound healing" @default.
- W567687002 hasPublicationYear "2013" @default.
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