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- W56775619 abstract "Abstract: Recently there has been intense interest to find if D deficiency may be related to cardiovascular disease, cancer and infection. Inadequate saturation with D may adversely affect immune and metabolic functions, causing non-skeletal medical disorders. Sunlight exposure induces D synthesis in the skin from a precursor, 7-dehydrocholesterol. Since the body produces D, this vitamin does not fulfill classical definition for a vitamin, being rather a prohormone. Vitamin D provided in the food has smaller role than the source synthesized in the skin. Vitamin D is hydroxylated in the liver into 25-OH-D. Because this product has a longer biological half life, it is the best indicator of body stores of D. Biologically active form is the next metabolite, 1-25 (OH)2 D. This product has a high binding affinity to a protein nuclear D receptor (VDR). Receptors for D have broad tissue distribution, including vascular smooth muscle, endothelium and even malignant cells. Deficiency of D in populations is high (30-60% in the USA and Europe). This is particularly true about the northern latitudes where there are insufficient UV-B rays to promote the skin synthesis. In addition, there are campaigns to control sun exposure (fear of skin cancer), together with reduction in outdoor activities. No wonder that in aging people, in chronically ill and in subjects requiring long-term hospitalization, deficiency of D is very frequent and may adversely affect already compromised immunologic functions and resistance to infection (Fig. 6, Ref. 43)." @default.
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- W56775619 date "2009-01-01" @default.
- W56775619 modified "2023-09-23" @default.
- W56775619 title "Vitamin D deficiency, atherosclerosis and cancer." @default.
- W56775619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20196468" @default.
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