Matches in SemOpenAlex for { <https://semopenalex.org/work/W567808897> ?p ?o ?g. }
- W567808897 endingPage "e1002169" @default.
- W567808897 startingPage "e1002169" @default.
- W567808897 abstract "Reciprocal coevolution between host and pathogen is widely seen as a major driver of evolution and biological innovation. Yet, to date, the underlying genetic mechanisms and associated trait functions that are unique to rapid coevolutionary change are generally unknown. We here combined experimental evolution of the bacterial biocontrol agent Bacillus thuringiensis and its nematode host Caenorhabditis elegans with large-scale phenotyping, whole genome analysis, and functional genetics to demonstrate the selective benefit of pathogen virulence and the underlying toxin genes during the adaptation process. We show that: (i) high virulence was specifically favoured during pathogen-host coevolution rather than pathogen one-sided adaptation to a nonchanging host or to an environment without host; (ii) the pathogen genotype BT-679 with known nematocidal toxin genes and high virulence specifically swept to fixation in all of the independent replicate populations under coevolution but only some under one-sided adaptation; (iii) high virulence in the BT-679-dominated populations correlated with elevated copy numbers of the plasmid containing the nematocidal toxin genes; (iv) loss of virulence in a toxin-plasmid lacking BT-679 isolate was reconstituted by genetic reintroduction or external addition of the toxins. We conclude that sustained coevolution is distinct from unidirectional selection in shaping the pathogen's genome and life history characteristics. To our knowledge, this study is the first to characterize the pathogen genes involved in coevolutionary adaptation in an animal host-pathogen interaction system." @default.
- W567808897 created "2016-06-24" @default.
- W567808897 creator A5002298394 @default.
- W567808897 creator A5003204898 @default.
- W567808897 creator A5007353681 @default.
- W567808897 creator A5009891235 @default.
- W567808897 creator A5012106795 @default.
- W567808897 creator A5020027850 @default.
- W567808897 creator A5027386188 @default.
- W567808897 creator A5036134061 @default.
- W567808897 creator A5050761530 @default.
- W567808897 creator A5054564152 @default.
- W567808897 creator A5067190376 @default.
- W567808897 creator A5072841736 @default.
- W567808897 creator A5080187191 @default.
- W567808897 creator A5080744109 @default.
- W567808897 creator A5083671398 @default.
- W567808897 creator A5084091189 @default.
- W567808897 creator A5084576936 @default.
- W567808897 creator A5086216056 @default.
- W567808897 creator A5088175400 @default.
- W567808897 date "2015-06-04" @default.
- W567808897 modified "2023-10-16" @default.
- W567808897 title "Host–Pathogen Coevolution: The Selective Advantage of Bacillus thuringiensis Virulence and Its Cry Toxin Genes" @default.
- W567808897 cites W1657713622 @default.
- W567808897 cites W1765152484 @default.
- W567808897 cites W1840360623 @default.
- W567808897 cites W1860078237 @default.
- W567808897 cites W1976398232 @default.
- W567808897 cites W1979427177 @default.
- W567808897 cites W1981369081 @default.
- W567808897 cites W1982286661 @default.
- W567808897 cites W2009021444 @default.
- W567808897 cites W2010854320 @default.
- W567808897 cites W2012016911 @default.
- W567808897 cites W2021410005 @default.
- W567808897 cites W2021724381 @default.
- W567808897 cites W2022201070 @default.
- W567808897 cites W2033067441 @default.
- W567808897 cites W2033121743 @default.
- W567808897 cites W2037438690 @default.
- W567808897 cites W2039582014 @default.
- W567808897 cites W2041257508 @default.
- W567808897 cites W2050454945 @default.
- W567808897 cites W2055097209 @default.
- W567808897 cites W2067108995 @default.
- W567808897 cites W2069894146 @default.
- W567808897 cites W2070190014 @default.
- W567808897 cites W2095763520 @default.
- W567808897 cites W2096441981 @default.
- W567808897 cites W2103441770 @default.
- W567808897 cites W2104767128 @default.
- W567808897 cites W2109407751 @default.
- W567808897 cites W2118266965 @default.
- W567808897 cites W2118807985 @default.
- W567808897 cites W2119573442 @default.
- W567808897 cites W2121911698 @default.
- W567808897 cites W2124985265 @default.
- W567808897 cites W2126334905 @default.
- W567808897 cites W2130582949 @default.
- W567808897 cites W2134523179 @default.
- W567808897 cites W2136155563 @default.
- W567808897 cites W2137779717 @default.
- W567808897 cites W2139760555 @default.
- W567808897 cites W2140843952 @default.
- W567808897 cites W2142537338 @default.
- W567808897 cites W2145928184 @default.
- W567808897 cites W2148181482 @default.
- W567808897 cites W2148979040 @default.
- W567808897 cites W2150506261 @default.
- W567808897 cites W2154397429 @default.
- W567808897 cites W2155046793 @default.
- W567808897 cites W2155668551 @default.
- W567808897 cites W2162806183 @default.
- W567808897 cites W2163708634 @default.
- W567808897 cites W2171848078 @default.
- W567808897 cites W4251055834 @default.
- W567808897 doi "https://doi.org/10.1371/journal.pbio.1002169" @default.
- W567808897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4456383" @default.
- W567808897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26042786" @default.
- W567808897 hasPublicationYear "2015" @default.
- W567808897 type Work @default.
- W567808897 sameAs 567808897 @default.
- W567808897 citedByCount "68" @default.
- W567808897 countsByYear W5678088972015 @default.
- W567808897 countsByYear W5678088972016 @default.
- W567808897 countsByYear W5678088972017 @default.
- W567808897 countsByYear W5678088972018 @default.
- W567808897 countsByYear W5678088972019 @default.
- W567808897 countsByYear W5678088972020 @default.
- W567808897 countsByYear W5678088972021 @default.
- W567808897 countsByYear W5678088972022 @default.
- W567808897 countsByYear W5678088972023 @default.
- W567808897 crossrefType "journal-article" @default.
- W567808897 hasAuthorship W567808897A5002298394 @default.
- W567808897 hasAuthorship W567808897A5003204898 @default.
- W567808897 hasAuthorship W567808897A5007353681 @default.
- W567808897 hasAuthorship W567808897A5009891235 @default.