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- W56803373 abstract "Women who have no children are more prone to mammary cancer than those who have them. Abstinence from sexual relations is associated with enhanced risk of uterine fibrosis and endometrial cancer, but a much-reduced risk of cancer of the uterine cervix. In some strains of rats the incidence of mammary tumors, mostly fibroadenomas, is almost 100% in old age. In other strans of rats, chromophobe adenomas of the p ituitary gland have a high incidence with age, and other tumors are also frequent. Overfeeding of laboratory rats and mice may contribute to the risk of developing tumors. Since 1972, there have been reports of liver tumors in women taking oral contraceptives (OC'S). Theoretically, hormones may increase cancer risk because of their hormonal activity or because they may be intrinsically carcinogenic. It is thought that cancer risk because of hormonal activity can be meaningfully studied in humans only by epidemiological methods. The chemistry of OCs makes it unlikely that they could have intrinsic carcinogenicity. This has been shown by large-scale long-term tests on laboratory animals. However, this is not adequate assurance that these drugs do not influence cancer risk in humans. Studies of the mechanisms of toxicology are needed." @default.
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- W56803373 date "1976-05-01" @default.
- W56803373 modified "2023-09-25" @default.
- W56803373 title "Possible Carcinogenic Hazards of Oral Contraception" @default.
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- W56803373 doi "https://doi.org/10.1177/003591577606900520" @default.
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