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- W568138830 abstract "Preface. 1: Introduction to Retroviruses and Retroviral Vectors G.L. Buchschacher Jr. Introduction. General Background and Classification of Retroviruses. The Retrovirus Genome and Virion Structure. The Retrovirus Replication Cycle. Elements of Retroviral Vector Systems. Summary. Acknowledgements. 2: HIV-1 Replication E.O. Freed. Introduction. The HIV-1 Replication Cycle. Role of the HIV Accessory Proteins in Virus Replication. Concluding Remarks. 3: Determinants for Lentiviral Infection of Non-Dividing Cells M.A. Vodicka. Introduction. Nuclear Transport. Transit of Non-Retroviral Particles. Retroviral Preintegration Complexes. Assays for Infection of Non-Dividing Cells. Viral Protein Determinants for HIV-1 Infection of Non-Dividing Cells. Viral Genome Structural Determinants. Summary and Conclusions. 4: HIV-1 Vector Systems N. Srinivasakumar. Introduction. HIV-1 Vector Systems Development. Clinical Applications of HIV-1 Vectors. Anticipated Developments in HIV-1-Based Packaging Systems and Possible Confounding Factors. Conclusions. Acknowledgements. 5: HIV-2 and SIV Vector Systems J.R. Gilbert, F. Wong-Staal. Introduction. Classification and Distribution. Pathology and Viral Replication. Genome Organization and Regulation. Vector Systems. Requiem and Prospectus. 6: Vector Systems S.L. Sauter, M. Gasmi. Epidemiology and Pathogenesis of FIV Infection. Development of FIV-Based Vectors. Acknowledgements. 7: EIAV, CIAV and Other Lentevirus Vector Systems J.C. Olsen. Introduction. Biological Similarities and Differences of Lenteviruses. Recent Vector Developments. 8: Safety Considerations in Vector Development. J.C. Kappes, Xiaoyun Wu. Introduction. Current Safety Design. Advancing Lenteviral Vectors Toward the Clinic. 9: Prospects for Gene Therapy Using HIV-Based Vectors Jiing-Kuan Yec, J.A. Zaia. Advantages of HIV Vectors Support Development. Attempts to Engineer Biosafety into HIV Vectors. Potential Clinical Applications of HIV Vectors. Regulatory Issues. Acknowledgements. 10: Ethical Considerations in the Use of Lenteviral Vectors for Genetic Transfer I. Roy. Introduction. Gene Therapy: Potentially Problematic Types of Application. General Ethical Considerations: Research and Clinical Settings. Summary. Index." @default.
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- W568138830 date "2003-01-01" @default.
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- W568138830 title "Lentiviral vector systems for gene transfer" @default.
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