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- W56878303 abstract "Pyridoxal 5’-phosphate (PLP) biosynthesis has been studied extensively inEscherichia coliK-12 by a combination of biochemical and genetic approaches, and theE. colipathway serves as a benchmark for understanding PLP biosynthesis in other organisms. The goal of this brief review is to highlight some of the genomic and genetic approaches that have contributed to delineating thede novoand salvage pathways of PLP biosynthesis inE. coli.Classical genetic approaches provided the initialpdxmutants, and the combination of genomics and genetics has helped to elucidate the functions and redundancy of enzymes involved in PLP biosynthesis. Genetic approaches have also verified intermediates in the PLP biosynthetic pathway in bacterial cells." @default.
- W56878303 created "2016-06-24" @default.
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- W56878303 date "2000-01-01" @default.
- W56878303 modified "2023-09-27" @default.
- W56878303 title "Genetic and Genomic Approaches for Delineating the Pathway of Pyridoxal 5’-Phosphate Coenzyme Biosynthesis in Escherichia coli" @default.
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- W56878303 doi "https://doi.org/10.1007/978-3-0348-8397-9_1" @default.
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