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- W56879401 abstract "Thegeneticparadigmof cancer— that tumorsariseas a consequenceof the accumulation of mutationsin genescontrollingcell proliferation, differentiation or death— is nowwidelyaccepted.The purpose of this is lectureprovidea reviewof currentknowledge on the varioustypes of cancer genes identifiedso far in different stages of tumordevelopment. Wewill alsoaddressrecentattempts to translatethe availablewealthof basic knowledgeon tumor genesinto clinicalapplicationsat the levelof diagnostics,prognosisor eventreatmentof this disease. Distinctclassesof cancergeneshavebeenoperationally identified.Dominantoncogenes, initiallyidentifiedbytransfection experiments, constitute thefirstmaingroupof humancancergenesidentifiedsincetheearly1980s.Theproductsof theirprecursor genesin normal cells— the protooncogenes — exertpositivecontrolovercell proliferation processes andtheirmutationin tumorsconfersthema dominant phenotype. Analysisof somaticcellhybridsbetweenneoplasticandnormal" @default.
- W56879401 created "2016-06-24" @default.
- W56879401 creator A5051459255 @default.
- W56879401 date "1999-01-01" @default.
- W56879401 modified "2023-09-27" @default.
- W56879401 title "Oncogenes andtumorsuppressor genes" @default.
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- W56879401 hasPublicationYear "1999" @default.
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