Matches in SemOpenAlex for { <https://semopenalex.org/work/W569085460> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W569085460 abstract "Lowering of tumor interstitial hypertension, which acts as a barrier for tumor transvascular transport, has been proposed as a general strategy to enhance tumor uptake and therapeutic effects of anticancer drugs. The tyrosine kinase platelet-derived growth factor (PDGF) beta-receptor is one mediator of tumor hypertension. The effects of PDGF antagonists on chemotherapy response were investigated in two tumor models that display PDGF receptor expression restricted to the tumor stroma, and in which PDGF antagonists relieve tumor hypertension. Inhibitory PDGF aptamers and the PDGF receptor tyrosine kinase inhibitor STI571 enhanced the antitumor effect of Taxol on s.c. KAT-4 tumors in SCID mice. Treatment with only PDGF antagonists had no effect on tumor growth. Taxol uptake in tumors was increased by treatment with PDGF antagonists. Cotreatment with PDGF antagonists and Taxol was not associated with antiangiogenic effects, and PDGF antagonists did not enhance the Taxol effect on in vitro growth of KAT-4 cells. STI571 also increased the antitumor effects of 5-fluorouracil on s.c. PROb tumors in syngeneic BDIX rats, without increasing the effect of 5-fluorouracil on cultured PROb cells. Expression of PDGF receptors in tumor stroma, as well as tumor hypertension, occurs in most common solid tumors. Therefore, our results have implications for treatment regimens for large patient groups and merit clinical testing. In conclusion, our study identifies inhibition of PDGF signaling in tumor stroma as a novel, possibly general strategy for enhancement of the therapeutic effects chemotherapy." @default.
- W569085460 created "2016-06-24" @default.
- W569085460 creator A5059726837 @default.
- W569085460 date "2002-01-01" @default.
- W569085460 modified "2023-09-24" @default.
- W569085460 title "Inhibition of PDGF receptor signaling in tumor stroma : Effects on interstitial hypertension, drug uptake and therapeutic response" @default.
- W569085460 hasPublicationYear "2002" @default.
- W569085460 type Work @default.
- W569085460 sameAs 569085460 @default.
- W569085460 citedByCount "0" @default.
- W569085460 crossrefType "dissertation" @default.
- W569085460 hasAuthorship W569085460A5059726837 @default.
- W569085460 hasConcept C101544691 @default.
- W569085460 hasConcept C121608353 @default.
- W569085460 hasConcept C126322002 @default.
- W569085460 hasConcept C170493617 @default.
- W569085460 hasConcept C180361614 @default.
- W569085460 hasConcept C204232928 @default.
- W569085460 hasConcept C2775960820 @default.
- W569085460 hasConcept C2778820342 @default.
- W569085460 hasConcept C2781294074 @default.
- W569085460 hasConcept C42362537 @default.
- W569085460 hasConcept C502942594 @default.
- W569085460 hasConcept C52124034 @default.
- W569085460 hasConcept C71924100 @default.
- W569085460 hasConcept C86803240 @default.
- W569085460 hasConcept C98274493 @default.
- W569085460 hasConceptScore W569085460C101544691 @default.
- W569085460 hasConceptScore W569085460C121608353 @default.
- W569085460 hasConceptScore W569085460C126322002 @default.
- W569085460 hasConceptScore W569085460C170493617 @default.
- W569085460 hasConceptScore W569085460C180361614 @default.
- W569085460 hasConceptScore W569085460C204232928 @default.
- W569085460 hasConceptScore W569085460C2775960820 @default.
- W569085460 hasConceptScore W569085460C2778820342 @default.
- W569085460 hasConceptScore W569085460C2781294074 @default.
- W569085460 hasConceptScore W569085460C42362537 @default.
- W569085460 hasConceptScore W569085460C502942594 @default.
- W569085460 hasConceptScore W569085460C52124034 @default.
- W569085460 hasConceptScore W569085460C71924100 @default.
- W569085460 hasConceptScore W569085460C86803240 @default.
- W569085460 hasConceptScore W569085460C98274493 @default.
- W569085460 hasLocation W5690854601 @default.
- W569085460 hasOpenAccess W569085460 @default.
- W569085460 hasPrimaryLocation W5690854601 @default.
- W569085460 hasRelatedWork W1887041030 @default.
- W569085460 hasRelatedWork W1914212739 @default.
- W569085460 hasRelatedWork W1982441587 @default.
- W569085460 hasRelatedWork W1991827817 @default.
- W569085460 hasRelatedWork W2040559235 @default.
- W569085460 hasRelatedWork W2051043829 @default.
- W569085460 hasRelatedWork W2054472190 @default.
- W569085460 hasRelatedWork W2064058095 @default.
- W569085460 hasRelatedWork W2088971478 @default.
- W569085460 hasRelatedWork W2097991473 @default.
- W569085460 hasRelatedWork W2108353976 @default.
- W569085460 hasRelatedWork W2114007536 @default.
- W569085460 hasRelatedWork W2124143152 @default.
- W569085460 hasRelatedWork W2127129194 @default.
- W569085460 hasRelatedWork W2148358344 @default.
- W569085460 hasRelatedWork W2150497617 @default.
- W569085460 hasRelatedWork W2162195775 @default.
- W569085460 hasRelatedWork W2164724907 @default.
- W569085460 hasRelatedWork W2174852849 @default.
- W569085460 hasRelatedWork W2183169576 @default.
- W569085460 isParatext "false" @default.
- W569085460 isRetracted "false" @default.
- W569085460 magId "569085460" @default.
- W569085460 workType "dissertation" @default.