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- W56912611 abstract "Diabetic neuropathy is a heterogeneous disorder that encompasses a wide range of abnormalities. Diabetic peripheral neuropathy (DPN) is the most frequent neurological complication of diabetes mellitus. Key factor in DPN pathophysiology seems to be decreased nerve blood flow, which determines functional and morphological nerve changes. Peripheral neuropathy along with foot deformities, and acute or chronic repetitive trauma are the triad of factors that contribute ultimately to diabetic foot ulceration (DFU). DFU is a serious secondary complication of diabetes mellitus that can potentially lead to devastating lower-extremity amputations. Impaired wound healing has been implicated as a significant cause for chronic DFU, since diabetes mellitus causes major abnormalities in all the four different phases of wound healing (hemostasis, inflammation, proliferation, and remodeling). The treatment cornerstones of DFU include regular debridement, pressure offloading, revascularization when appropriate, adequate treatment of infection, and local wound care." @default.
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- W56912611 date "2012-01-01" @default.
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- W56912611 title "Role of Peripheral Neuropathy in the Development of Foot Ulceration and Impaired Wound Healing in Diabetes Mellitus" @default.
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- W56912611 doi "https://doi.org/10.1016/b978-0-12-385083-6.00015-2" @default.
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