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- W56914581 abstract "OBJECTIVE To study the effect of aldosterone on aquaporin and ionophorous protein expressions in the cochlea of guinea pigs. METHODS RT-PCR was used to detect the expression of Na-K ATPase and epithelial sodium channel (ENaC) mRNA in the cochlea of guinea pigs 6 h after intraperitoneal aldosterone injection. Immunohistochemistry was used to detect the expression of aquaporin 1(AQP1) in the cochlea 1 month after the injection. RESULTS Early after aldosterone injection, the expression level of Na-K ATPase beta(1) and beta(3) subunit mRNAs remained unchanged and level of ENaC alpha subunit mRNA was up-regulated in the cochlear lateral wall (P<0.05), and 1 month after the injection, the expression of AQP1 protein was down-regulated (P<0.05). CONCLUSION The effect of aldosterone on the cochlea is mediated possibly through its action on the genome, and aldosterone may cause ion concentration alterations to induce endolymphatic hydrops." @default.
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- W56914581 date "2007-12-01" @default.
- W56914581 modified "2023-09-23" @default.
- W56914581 title "Effect of aldosterone on aquaporin and ionophorous protein expressions in guinea pig cochlea" @default.
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