Matches in SemOpenAlex for { <https://semopenalex.org/work/W569157409> ?p ?o ?g. }
- W569157409 endingPage "e0129452" @default.
- W569157409 startingPage "e0129452" @default.
- W569157409 abstract "Change in the host and/or human papillomavirus (HPV) DNA methylation profile is probably one of the main factors responsible for the malignant progression of cervical lesions to cancer. To investigate those changes we studied 173 cervical samples with different grades of cervical lesion, from normal to cervical cancer. The methylation status of nine cellular gene promoters, CCNA1, CDH1, C13ORF18, DAPK1, HIC1, RARβ2, hTERT1, hTERT2 and TWIST1, was investigated by Methylation Specific Polymerase Chain Reaction (MSP). The methylation of HPV18 L1-gene was also investigated by MSP, while the methylated cytosines within four regions, L1, 5'LCR, enhancer, and promoter of the HPV16 genome covering 19 CpG sites were evaluated by bisulfite sequencing. Statistically significant methylation biomarkers distinguishing between cervical precursor lesions from normal cervix were primarily C13ORF18 and secondly CCNA1, and those distinguishing cervical cancer from normal or cervical precursor lesions were CCNA1, C13ORF18, hTERT1, hTERT2 and TWIST1. In addition, the methylation analysis of individual CpG sites of the HPV16 genome in different sample groups, notably the 7455 and 7694 sites, proved to be more important than the overall methylation frequency. The majority of HPV18 positive samples contained both methylated and unmethylated L1 gene, and samples with L1-gene methylated forms alone had better prognosis when correlated with the host cell gene promoters' methylation profiles. In conclusion, both cellular and viral methylation biomarkers should be used for monitoring cervical lesion progression to prevent invasive cervical cancer." @default.
- W569157409 created "2016-06-24" @default.
- W569157409 creator A5010245729 @default.
- W569157409 creator A5012184499 @default.
- W569157409 creator A5031380965 @default.
- W569157409 creator A5043072081 @default.
- W569157409 creator A5043828648 @default.
- W569157409 creator A5046433020 @default.
- W569157409 creator A5069614653 @default.
- W569157409 date "2015-06-09" @default.
- W569157409 modified "2023-10-14" @default.
- W569157409 title "Methylated Host Cell Gene Promoters and Human Papillomavirus Type 16 and 18 Predicting Cervical Lesions and Cancer" @default.
- W569157409 cites W1495272710 @default.
- W569157409 cites W1496182593 @default.
- W569157409 cites W1763688420 @default.
- W569157409 cites W1861883318 @default.
- W569157409 cites W1945270539 @default.
- W569157409 cites W1963744267 @default.
- W569157409 cites W1964783528 @default.
- W569157409 cites W1966320481 @default.
- W569157409 cites W1975382880 @default.
- W569157409 cites W2004172747 @default.
- W569157409 cites W2009504586 @default.
- W569157409 cites W2018906190 @default.
- W569157409 cites W2023942950 @default.
- W569157409 cites W2024819383 @default.
- W569157409 cites W2051614385 @default.
- W569157409 cites W2055035941 @default.
- W569157409 cites W2064830547 @default.
- W569157409 cites W2065528684 @default.
- W569157409 cites W2069698023 @default.
- W569157409 cites W2073528014 @default.
- W569157409 cites W2078660981 @default.
- W569157409 cites W2093583952 @default.
- W569157409 cites W2096707280 @default.
- W569157409 cites W2098744299 @default.
- W569157409 cites W2109892705 @default.
- W569157409 cites W2118549850 @default.
- W569157409 cites W2119594769 @default.
- W569157409 cites W2120446357 @default.
- W569157409 cites W2121417064 @default.
- W569157409 cites W2130345058 @default.
- W569157409 cites W2131459766 @default.
- W569157409 cites W2131605978 @default.
- W569157409 cites W2132384241 @default.
- W569157409 cites W2137251820 @default.
- W569157409 cites W2137960843 @default.
- W569157409 cites W2139736159 @default.
- W569157409 cites W2148240313 @default.
- W569157409 cites W2162617056 @default.
- W569157409 cites W2163211026 @default.
- W569157409 cites W2165587740 @default.
- W569157409 cites W2166632132 @default.
- W569157409 cites W2167533065 @default.
- W569157409 cites W2168745469 @default.
- W569157409 cites W9248791 @default.
- W569157409 cites W94283765 @default.
- W569157409 doi "https://doi.org/10.1371/journal.pone.0129452" @default.
- W569157409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4461273" @default.
- W569157409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26057381" @default.
- W569157409 hasPublicationYear "2015" @default.
- W569157409 type Work @default.
- W569157409 sameAs 569157409 @default.
- W569157409 citedByCount "21" @default.
- W569157409 countsByYear W5691574092016 @default.
- W569157409 countsByYear W5691574092017 @default.
- W569157409 countsByYear W5691574092018 @default.
- W569157409 countsByYear W5691574092019 @default.
- W569157409 countsByYear W5691574092020 @default.
- W569157409 countsByYear W5691574092021 @default.
- W569157409 countsByYear W5691574092023 @default.
- W569157409 crossrefType "journal-article" @default.
- W569157409 hasAuthorship W569157409A5010245729 @default.
- W569157409 hasAuthorship W569157409A5012184499 @default.
- W569157409 hasAuthorship W569157409A5031380965 @default.
- W569157409 hasAuthorship W569157409A5043072081 @default.
- W569157409 hasAuthorship W569157409A5043828648 @default.
- W569157409 hasAuthorship W569157409A5046433020 @default.
- W569157409 hasAuthorship W569157409A5069614653 @default.
- W569157409 hasBestOaLocation W5691574091 @default.
- W569157409 hasConcept C101762097 @default.
- W569157409 hasConcept C104317684 @default.
- W569157409 hasConcept C121608353 @default.
- W569157409 hasConcept C140173407 @default.
- W569157409 hasConcept C150194340 @default.
- W569157409 hasConcept C153911025 @default.
- W569157409 hasConcept C189235521 @default.
- W569157409 hasConcept C190727270 @default.
- W569157409 hasConcept C2778220009 @default.
- W569157409 hasConcept C33288867 @default.
- W569157409 hasConcept C502942594 @default.
- W569157409 hasConcept C54355233 @default.
- W569157409 hasConcept C86803240 @default.
- W569157409 hasConceptScore W569157409C101762097 @default.
- W569157409 hasConceptScore W569157409C104317684 @default.
- W569157409 hasConceptScore W569157409C121608353 @default.
- W569157409 hasConceptScore W569157409C140173407 @default.
- W569157409 hasConceptScore W569157409C150194340 @default.