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- W569311908 abstract "276 Objectives Targeting of integrin ανβ3 with molecular imaging agents offers great potential in early detection and monitoring of tumour angiogenesis. Recently, an RGD (Arg-Gly-Asp) tracer, 99mTc-3P4-RGD2 was developed. In this study, we evaluate the feasibility of this novel radiotracer in the noninvasive differentiation of solitary pulmonary nodules (SPNs). Methods Twenty-one patients with SPNs on CT were studied scintigraphically after administration of 99mTc-3P4-RGD2 with a dose of 939MBq. Image interpretation using a 5-point scale was performed for CT and SPECT. Scintigraphic images were also analysed semiquantitatively by calculating tumour to normal tissue ratio (T/N). The “gold standard” was based on the histopathological diagnosis of the surgical samples from all recruited patients. Results Among the 21 SPNs, 15 (71%) were diagnosed as malignant and 6 (29%) were benign. The mean size for SPNs was 2.2 cm. The sensitivity and specificity for CT interpretation, SPECT visual and semiquantitative analysis were 80/67%, 100/67% and 100/67%, respectively. All SPNs classified as indeterminate by CT were correctly diagnosed by 99mTc-3P4-RGD2 scintigraphy. The empirical receiver-operating characteristic (ROC) areas were 0.811 [95% confidence interval (CI) 58-95%] for CT, 0.833 (95% CI 61-96%) for SPECT and 0.844 (95% CI 62-96%) for T/N ratios, respectively. Conclusions In this first-in-human study, we demonstrated the feasibility of using 99mTc-3P4-RGD2 scintigraphy in differentiating SPNs. This procedure appears to be highly sensitive in detection of malignant SPNs. Research Support Research Fund of Science and Technology Department of Jilin Province (no. 201015185)" @default.
- W569311908 created "2016-06-24" @default.
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- W569311908 date "2012-05-01" @default.
- W569311908 modified "2023-09-24" @default.
- W569311908 title "Differential diagnosis of solitary pulmonary nodules using 99mTc-3P4-RGD2 scintigraphy" @default.
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