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- W56975810 abstract "Cognitive dysfunction and behavioral abnormalities resulting from synaptic degeneration and death of neurons in limbic and cortical brain regions are defining features of Alzheimer’s disease (AD). The impact of AD on our aging society is dramatically increasing, and projections indicate that up to 20 million Americans will have AD by the year 2020. When considered together with the other chapters in this volume, it is therefore apparent that age-related neurodegenerative disorders will very soon become the major health problem in industrialized countries, superseding cardiovascular disease and cancer. A synthesis of the data described in the different chapters reveals that several features of the neurodegenerative process are shared among the disorders including: increased levels of oxidative stress, metabolic compromise, mitochondrial dysfunction, activation of apoptotic biochemical cascades, perturbed calcium regulation, and abnormalities in protein processing/degradation. The present chapter integrates the available data obtained from analyses of AD patients and experimental cell culture and animal models of AD so as to provide a framework that will guide future research in this field, as well as the development of preventative and therapeutic approaches. Because increasing age is the major risk factor for AD, it is not surprising that age-related alterations, including increased levels of oxidative stress and metabolic aberrancies, are believed to contribute greatly to the neurodegenerative process (Hoyer et al., 1991; Jagust et al., 1991; Butterfield and Stadtman, 1997; Mattson and Pedersen, 1998)." @default.
- W56975810 created "2016-06-24" @default.
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- W56975810 date "2001-01-01" @default.
- W56975810 modified "2023-09-23" @default.
- W56975810 title "Cellular and Molecular Mechanisms Underlying Synaptic Degeneration and Neuronal Death in Alzheimer’s Disease" @default.
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