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- W569863743 abstract "多发性硬化症（MS）患者存在通过凋亡清除自身反应性T细胞功能的缺陷，Glatiramer acetate（GA）治疗似乎能恢复有害T细胞的凋亡。对复发-缓解型（RR）MS患者接受GA治疗期间外周淋巴细胞中线粒体膜促凋亡蛋白（Bax）、抗凋亡蛋白（Bcl-2）和细胞浆促凋亡蛋白（Cyt-c和APAF-1）的表达情况进行分析。收集8例健康对照者（HCs）的血液标本，并收集8例RRMS患者治疗前和9个月GA治疗过程中每3个月的血液标本。采用蛋白印记法以及光密度扫描对周围血单核细胞（PBMNCs）中的Bcl-2、Bax、Cyt-c和APAF-1含量进行定量分析，并计算Bax／Bcl-2、胞浆Cyt—c／Bcl-2和APAF-1／Bcl-2的比值，通过对T细胞进行体外呼吸测量分析来测定其氧耗量。未治疗MS患者的Bax／Bcl-2、胞浆Cyt-c／Bcl-2和APAF-1／Bcl-2的比值显著低于HCs（P〈0．05），MS患者接受GA治疗的9个月过程中Bax／Bcl-2增加（P=0．03），Cyt-c／Bcl-2也呈增加趋势。GA治疗后较治疗前或GA治疗患者的细胞较HCs细胞中的PBMNCs体外氧耗量分别显著减少58％和59％。本结果提示GA通过包含线粒体和细胞浆蛋白的促凋亡机制发挥其对周围T淋巴细胞的调节作用。" @default.
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- W569863743 date "2006-01-01" @default.
- W569863743 modified "2023-09-23" @default.
- W569863743 title "Glatiramer acetate诱导多发性硬化症患者周围淋巴细胞包括Bcl-2、Bax和Cyt-c在内的促凋亡机制" @default.
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