Matches in SemOpenAlex for { <https://semopenalex.org/work/W569883319> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W569883319 abstract "Aging is associated with pro-inflammatory phenotypic changes in blood vessels, which is likely to contribute to the increased cardiovascular morbidity and decline in organ functions in elderly patients. Resveratrol, a polyphenolic stilbene derivate found in more than 70 plants has been proposed to exert beneficial anti-oxidant and anti-inflammatory effects in cardiovascular disease. In addition, in lower organisms (C. elegans, D. melanogaster) resveratrol exerts anti-aging effects extending the lifespan. To test the hypothesis that resveratrol exerts vasculoprotective effects in mammalian aging we assessed its effects on the function and phenotype of blood vessels of young (Y, 3 month old) and aged (A, 29 month old) F344 rats. Resveratrol (10-5 to 3x10-4 mol/L) elicited concentration-dependent relaxations of mesenteric arterioles and carotid arteries, which were preserved in aging. In vessels of aged rats there was an impaired dilation to acetylcholine (at 3x10-6 mol/L, Y: 89±4%, A: 48±15%) and an increased superoxide production, that were not affected significantly by in vitro administration of resveratrol. Endothelial function was also unaffected in aged rats with in vivo resveratrol treatment (3 mg/kg/day for 1 week). Vascular expression of the inflammatory markers iNOS and ICAM-1 was significantly increased with age and was attenuated by resveratrol treatment (in organoid culture). In vivo resveratrol treatment also decreased expression of inflammatory markers. Thus, we propose that anti-inflammatory action of resveratrol may offer novel anti-aging cardioprotective therapeutic strategies. (Grant support: AHA 0430108N, 0435140N, American Federation for Aging Research, AHAF H2004-024; California Grape Commission)." @default.
- W569883319 created "2016-06-24" @default.
- W569883319 creator A5006685141 @default.
- W569883319 creator A5021282382 @default.
- W569883319 creator A5021351628 @default.
- W569883319 creator A5042912976 @default.
- W569883319 creator A5053748854 @default.
- W569883319 creator A5077289645 @default.
- W569883319 date "2006-03-01" @default.
- W569883319 modified "2023-10-18" @default.
- W569883319 title "Resveratrol may attenuate vascular inflammation in aging" @default.
- W569883319 doi "https://doi.org/10.1096/fasebj.20.5.a1085-c" @default.
- W569883319 hasPublicationYear "2006" @default.
- W569883319 type Work @default.
- W569883319 sameAs 569883319 @default.
- W569883319 citedByCount "1" @default.
- W569883319 countsByYear W5698833192023 @default.
- W569883319 crossrefType "journal-article" @default.
- W569883319 hasAuthorship W569883319A5006685141 @default.
- W569883319 hasAuthorship W569883319A5021282382 @default.
- W569883319 hasAuthorship W569883319A5021351628 @default.
- W569883319 hasAuthorship W569883319A5042912976 @default.
- W569883319 hasAuthorship W569883319A5053748854 @default.
- W569883319 hasAuthorship W569883319A5077289645 @default.
- W569883319 hasConcept C126322002 @default.
- W569883319 hasConcept C134018914 @default.
- W569883319 hasConcept C150903083 @default.
- W569883319 hasConcept C207001950 @default.
- W569883319 hasConcept C2776816829 @default.
- W569883319 hasConcept C2776820930 @default.
- W569883319 hasConcept C2776914184 @default.
- W569883319 hasConcept C2780771799 @default.
- W569883319 hasConcept C71924100 @default.
- W569883319 hasConcept C86803240 @default.
- W569883319 hasConcept C98274493 @default.
- W569883319 hasConceptScore W569883319C126322002 @default.
- W569883319 hasConceptScore W569883319C134018914 @default.
- W569883319 hasConceptScore W569883319C150903083 @default.
- W569883319 hasConceptScore W569883319C207001950 @default.
- W569883319 hasConceptScore W569883319C2776816829 @default.
- W569883319 hasConceptScore W569883319C2776820930 @default.
- W569883319 hasConceptScore W569883319C2776914184 @default.
- W569883319 hasConceptScore W569883319C2780771799 @default.
- W569883319 hasConceptScore W569883319C71924100 @default.
- W569883319 hasConceptScore W569883319C86803240 @default.
- W569883319 hasConceptScore W569883319C98274493 @default.
- W569883319 hasFunder F4320306229 @default.
- W569883319 hasFunder F4320306230 @default.
- W569883319 hasIssue "5" @default.
- W569883319 hasLocation W5698833191 @default.
- W569883319 hasOpenAccess W569883319 @default.
- W569883319 hasPrimaryLocation W5698833191 @default.
- W569883319 hasRelatedWork W1978821382 @default.
- W569883319 hasRelatedWork W1990861034 @default.
- W569883319 hasRelatedWork W2018075260 @default.
- W569883319 hasRelatedWork W2020128704 @default.
- W569883319 hasRelatedWork W2078987736 @default.
- W569883319 hasRelatedWork W2091193686 @default.
- W569883319 hasRelatedWork W2147053026 @default.
- W569883319 hasRelatedWork W2162471541 @default.
- W569883319 hasRelatedWork W2167226448 @default.
- W569883319 hasRelatedWork W2331977114 @default.
- W569883319 hasVolume "20" @default.
- W569883319 isParatext "false" @default.
- W569883319 isRetracted "false" @default.
- W569883319 magId "569883319" @default.
- W569883319 workType "article" @default.