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• W57008086 abstract "CD97 was identified as an early activation marker on T cells, having low expression on naive T cells. This is a common feature of molecules that have a role in T-cell function. It was subsequently identified as a ligand for CD55, which has been previously identified as an innate regulator of complement. The interaction of this receptor-ligand pair has been shown to provide a potent costimulatory signal to human T cells, despite their modest affinity. Though both CD97 and CD55 are expressed on T cells as well as antigen presenting cells (APCs), their interaction is significant when CD97 on APCs interacts with CD55 on T cells. The converse interaction is poorly defined and may be less significant. A unique aspect of the interaction of CD97 with CD55 is the stimulation of naive T cells, leading to the induction of IL-10 producing cells that behave like Trl regulatory cells. This raises a number of questions regarding the dual functions of CD55; regulating complement and stimulating T cells via CD97 interaction and any potential overlap in the consequences of these dual roles." @default.
• W57008086 created "2016-06-24" @default.
• W57008086 creator A5076464720 @default.
• W57008086 creator A5080130390 @default.
• W57008086 date "2010-01-01" @default.
• W57008086 modified "2023-10-02" @default.
• W57008086 title "The Role of CD97 in Regulating Adaptive T-Cell Responses" @default.
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• W57008086 doi "https://doi.org/10.1007/978-1-4419-7913-1_12" @default.
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