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- W570671240 endingPage "1149" @default.
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- W570671240 abstract "Human eukaryotic prohibitin (prohibitin-1 and prohibitin-2) is a membrane protein with different cellular localizations. It is involved in multiple cellular functions, including energy metabolism, proliferation, apoptosis, and senescence. The subcellular localization of prohibitin may determine its functions. Membrane prohibitin regulate the cellular signaling of membrane transport, nuclear prohibitin control transcription activation and the cell cycle, and mitochondrial prohibitin complex stabilize the mitochondrial genome and modulate mitochondrial dynamics, mitochondrial morphology, mitochondrial biogenesis, and the mitochondrial intrinsic apoptotic pathway. Moreover, prohibitin can translocates into the nucleus or the mitochondria under apoptotic signals and the subcellular shuttling of prohibitin is necessary for apoptosis process. Apoptosis is the process of programmed cell death that is important for the maintenance of normal physiological functions. Consequently, any alteration in the content, post-transcriptional modification (i.e. phosphorylation) or the nuclear or mitochondrial translocation of prohibitin may influence cell fate. Understanding the mechanisms of the expression and regulation of prohibitin may be useful for future research. This review provides an overview of the multifaceted and essential roles played by prohibitin in the regulation of cell survival and apoptosis." @default.
- W570671240 created "2016-06-24" @default.
- W570671240 creator A5000021360 @default.
- W570671240 creator A5008226996 @default.
- W570671240 creator A5069847554 @default.
- W570671240 creator A5071621068 @default.
- W570671240 date "2015-06-20" @default.
- W570671240 modified "2023-10-16" @default.
- W570671240 title "Multifaceted role of prohibitin in cell survival and apoptosis" @default.
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