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- W570784807 abstract "p27Kip1 (p27) is a critical cyclin dependent kinase inhibitor that negatively regulates cell cycle progression from G1 to S phase. Levels of nuclear p27 are reduced in many human cancers. Both the levels and function of p27 are regulated by transcriptional, translational, and posttranslational mechanisms. In regulating p27, posttranslational phosphorylation of the protein is particularly important for determining susceptibility to ubiquitination and proteolytic degradation, as well as the levels, subcellular localization, and functional activity of p27. In addition to the control of cell cycle, cytoplasmic expression of p27 can enhance cell motility, increase renewal of stem cells, inhibit apoptosis, induce autophagy, and stimulate tumor metastasis. Persistence of nuclear p27 provides an independent favorable prognostic factor in many human cancers. Expression or induction of p27 may provide a predictive biomarker for response to chemotherapy, hormonal therapy, and at least some targeted therapies including trastuzumab and Src inhibitors. In addition, restoration of nuclear p27 levels might be achieved pharmacologically, inhibiting proliferation of cancer cells. Inhibition of SKP2-mediated p27 ubiquitination provides one additional promising approach." @default.
- W570784807 created "2016-06-24" @default.
- W570784807 creator A5067595997 @default.
- W570784807 creator A5077290971 @default.
- W570784807 date "2009-08-19" @default.
- W570784807 modified "2023-10-17" @default.
- W570784807 title "p27Kip1 as a Biomarker and Target for Treatment of Cancer" @default.
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