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- W570942 abstract "Spindle waves are a heuristic example of synchronized oscillations, a common product of thalamic and cortical systems in sleeping and waking animals. The physiological bases for the generation of spindle waves were investigated with extracellular and intracellular recording techniques in slices of ferret dorsal lateral geniculate nucleus (LGNd) maintained in vitro. The neural circuit preserved in the slice preparation generates spontaneous spindle waves every 5–30 seconds, with an intraspindle frequency of 6–10 Hz. Based on experimental data, we propose a model that describes the spindle wave oscillation from the level of the synaptic network down to the level of the ionic conductances of the neurons involved in the activity. In addition, we examine the mechanisms by which spindle waves in the LGNd are transformed, after pharmacological block of GABAA receptors, into vigorous and hyper-synchronous oscillations that resemble those of absence (petit mal) seizures of generalized epilepsy." @default.
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- W570942 date "1994-01-01" @default.
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- W570942 title "From Cellular to Network Mechanisms of a Thalamic Synchronized Oscillation" @default.
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- W570942 doi "https://doi.org/10.1007/978-3-642-85148-3_8" @default.
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