Matches in SemOpenAlex for { <https://semopenalex.org/work/W571488475> ?p ?o ?g. }
- W571488475 endingPage "13" @default.
- W571488475 startingPage "7" @default.
- W571488475 abstract "In this study to examine the cytotoxic property of tetracaine, we cytometrically examined the effect of tetracaine on intracellular Zn concentration by the use of FluoZin-3, a fluorescent indicator of intracellular Zn. Lidocaine was used as a reference drug. The incubation of rat thymocytes with tetracaine decreased the intensity of FluoZin-3 fluorescence while that with lidocaine increased the intensity. The incubation with 10 μM DTPA, a chelator for extracellular Zn, attenuated the tetracaine-induced decrease in fluorescence intensity. The application of ZnCl2 augmented FluoZin-3 fluorescence. The augmentation by ZnCl2 was a temperature-sensitive. Tetracaine attenuated the ZnCl2-induced augmentation of FluoZin-3 fluorescence. Taken together, the results suggest that tetracaine attenuates membrane Zn influx, resulting in a decrease in intracellular Zn concentration in rat thymocytes. Although the cells in this study are not targets for actions of local anesthetics, the result may give one clue to explain the difference between the cytotoxicity of local anesthetics since the action of tetracaine on FluoZin-3 fluorescence was opposite to that of lidocaine." @default.
- W571488475 created "2016-06-24" @default.
- W571488475 creator A5005436782 @default.
- W571488475 creator A5060700088 @default.
- W571488475 creator A5060976717 @default.
- W571488475 creator A5086796562 @default.
- W571488475 creator A5087373299 @default.
- W571488475 creator A5088366793 @default.
- W571488475 date "2011-01-01" @default.
- W571488475 modified "2023-09-24" @default.
- W571488475 title "Tetracaine decreases intracellular Zn²⁺ concentration by inhibiting Zn²⁺ influx in rat thymocytes" @default.
- W571488475 cites W1568628619 @default.
- W571488475 cites W1607531254 @default.
- W571488475 cites W1798204859 @default.
- W571488475 cites W1912081610 @default.
- W571488475 cites W1981980661 @default.
- W571488475 cites W1989452037 @default.
- W571488475 cites W1990296652 @default.
- W571488475 cites W1993949519 @default.
- W571488475 cites W1999103491 @default.
- W571488475 cites W1999296675 @default.
- W571488475 cites W2007853535 @default.
- W571488475 cites W2027181851 @default.
- W571488475 cites W2037617419 @default.
- W571488475 cites W2041059461 @default.
- W571488475 cites W2042073086 @default.
- W571488475 cites W2051485869 @default.
- W571488475 cites W2057958952 @default.
- W571488475 cites W2098691426 @default.
- W571488475 cites W2100658303 @default.
- W571488475 cites W2100723302 @default.
- W571488475 cites W2118602240 @default.
- W571488475 cites W2124684134 @default.
- W571488475 cites W2126143610 @default.
- W571488475 cites W2133581650 @default.
- W571488475 cites W2138149556 @default.
- W571488475 cites W2142419903 @default.
- W571488475 cites W2159050142 @default.
- W571488475 cites W2159554322 @default.
- W571488475 cites W2162184782 @default.
- W571488475 cites W2170901098 @default.
- W571488475 cites W2338136852 @default.
- W571488475 cites W2397954748 @default.
- W571488475 cites W2444175175 @default.
- W571488475 cites W77282717 @default.
- W571488475 cites W88594106 @default.
- W571488475 hasPublicationYear "2011" @default.
- W571488475 type Work @default.
- W571488475 sameAs 571488475 @default.
- W571488475 citedByCount "2" @default.
- W571488475 countsByYear W5714884752012 @default.
- W571488475 crossrefType "journal-article" @default.
- W571488475 hasAuthorship W571488475A5005436782 @default.
- W571488475 hasAuthorship W571488475A5060700088 @default.
- W571488475 hasAuthorship W571488475A5060976717 @default.
- W571488475 hasAuthorship W571488475A5086796562 @default.
- W571488475 hasAuthorship W571488475A5087373299 @default.
- W571488475 hasAuthorship W571488475A5088366793 @default.
- W571488475 hasConcept C121332964 @default.
- W571488475 hasConcept C12554922 @default.
- W571488475 hasConcept C185592680 @default.
- W571488475 hasConcept C25642318 @default.
- W571488475 hasConcept C2778455913 @default.
- W571488475 hasConcept C2780149897 @default.
- W571488475 hasConcept C28406088 @default.
- W571488475 hasConcept C42219234 @default.
- W571488475 hasConcept C55493867 @default.
- W571488475 hasConcept C62520636 @default.
- W571488475 hasConcept C71924100 @default.
- W571488475 hasConcept C79879829 @default.
- W571488475 hasConcept C86803240 @default.
- W571488475 hasConcept C91881484 @default.
- W571488475 hasConcept C98274493 @default.
- W571488475 hasConceptScore W571488475C121332964 @default.
- W571488475 hasConceptScore W571488475C12554922 @default.
- W571488475 hasConceptScore W571488475C185592680 @default.
- W571488475 hasConceptScore W571488475C25642318 @default.
- W571488475 hasConceptScore W571488475C2778455913 @default.
- W571488475 hasConceptScore W571488475C2780149897 @default.
- W571488475 hasConceptScore W571488475C28406088 @default.
- W571488475 hasConceptScore W571488475C42219234 @default.
- W571488475 hasConceptScore W571488475C55493867 @default.
- W571488475 hasConceptScore W571488475C62520636 @default.
- W571488475 hasConceptScore W571488475C71924100 @default.
- W571488475 hasConceptScore W571488475C79879829 @default.
- W571488475 hasConceptScore W571488475C86803240 @default.
- W571488475 hasConceptScore W571488475C91881484 @default.
- W571488475 hasConceptScore W571488475C98274493 @default.
- W571488475 hasLocation W5714884751 @default.
- W571488475 hasOpenAccess W571488475 @default.
- W571488475 hasPrimaryLocation W5714884751 @default.
- W571488475 hasRelatedWork W1494793612 @default.
- W571488475 hasRelatedWork W1652811187 @default.
- W571488475 hasRelatedWork W1966409075 @default.
- W571488475 hasRelatedWork W1968632871 @default.
- W571488475 hasRelatedWork W1973522109 @default.
- W571488475 hasRelatedWork W1974637880 @default.
- W571488475 hasRelatedWork W1992381919 @default.