FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W57149703> ?p ?o ?g. }

• W57149703 abstract "The sequential development of hepatic nodules induced by phenobarbitone (PB) has been studied in the C3H/He strain of mouse, a strain prone to the development of spontaneous liver tumours. PB was administered in the diet to young male animals at a dose level of 85 mg/kg/day for up to 91 weeks. Control and PB-treated mice developed hepatic nodules within 60 weeks. In control animals the nodules consisted of small basophilic cells, and by 80 weeks a small proportion of the animals had developed unequivocal hepatocellular carcinoma. The basophilic nodules were similar in many respects to those induced by N-nitrosodiethylamine. In PB-treated mice the incidence of basophilic nodules was similar to that in controls. These animals also developed hepatic nodules formed of large eosinophilic cells which were readily dissectable from the surrounding host tissue by 60 weeks. Biochemical investigations into the large eosinophilic nodules from PB treated mice showed that both Phase I and Phase II types of xenobiotic metabolizing enzyme activities were induced to levels either similar to, or greater than in the surrounding host tissue. In contrast, enzyme activities in basophilic nodules from untreated mice killed at 91 weeks, were generally similar to or lower than in the surrounding host tissue. The presence of eosinophilic nodules did not lead to an increase in the incidence of hepatocellular carcinoma in the PB-treated C3H/He mice. Concurrent experiments conducted in the C57BL/6 strain of mouse did not result in the development of liver nodules at 60 weeks. Thus, the eosinophilic nodules induced by phenobarbitone in C3H/He mice appear to be distinctly different from the basophilic liver nodules arising spontaneously or to basophilic nodules produced by the hepatocellular carcinogen N-nitrosodiethylamine." @default.
• W57149703 created "2016-06-24" @default.
• W57149703 creator A5019059474 @default.
• W57149703 creator A5072623198 @default.
• W57149703 creator A5080260120 @default.
• W57149703 date "1987-01-01" @default.
• W57149703 modified "2023-09-25" @default.
• W57149703 title "The Histopathology and Biochemistry of Phenobarbitone-Induced Liver Nodules in C3H Mice" @default.
• W57149703 cites W1964039364 @default.
• W57149703 cites W2008206518 @default.
• W57149703 cites W2025134515 @default.
• W57149703 cites W2028064159 @default.
• W57149703 cites W2030042037 @default.
• W57149703 cites W2030129122 @default.
• W57149703 cites W2055977036 @default.
• W57149703 cites W2066679763 @default.
• W57149703 cites W2072891772 @default.
• W57149703 cites W2079683622 @default.
• W57149703 cites W2147771544 @default.
• W57149703 cites W2167804500 @default.
• W57149703 doi "https://doi.org/10.1007/978-3-642-71617-1_8" @default.
• W57149703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3472502" @default.
• W57149703 hasPublicationYear "1987" @default.
• W57149703 type Work @default.
• W57149703 sameAs 57149703 @default.
• W57149703 citedByCount "9" @default.
• W57149703 countsByYear W571497032012 @default.
• W57149703 countsByYear W571497032020 @default.
• W57149703 crossrefType "book-chapter" @default.
• W57149703 hasAuthorship W57149703A5019059474 @default.
• W57149703 hasAuthorship W57149703A5072623198 @default.
• W57149703 hasAuthorship W57149703A5080260120 @default.
• W57149703 hasConcept C142724271 @default.
• W57149703 hasConcept C19210678 @default.
• W57149703 hasConcept C2778019345 @default.
• W57149703 hasConcept C2779758542 @default.
• W57149703 hasConcept C502942594 @default.
• W57149703 hasConcept C544855455 @default.
• W57149703 hasConcept C71924100 @default.
• W57149703 hasConcept C86803240 @default.
• W57149703 hasConceptScore W57149703C142724271 @default.
• W57149703 hasConceptScore W57149703C19210678 @default.
• W57149703 hasConceptScore W57149703C2778019345 @default.
• W57149703 hasConceptScore W57149703C2779758542 @default.
• W57149703 hasConceptScore W57149703C502942594 @default.
• W57149703 hasConceptScore W57149703C544855455 @default.
• W57149703 hasConceptScore W57149703C71924100 @default.
• W57149703 hasConceptScore W57149703C86803240 @default.
• W57149703 hasLocation W571497031 @default.
• W57149703 hasLocation W571497032 @default.
• W57149703 hasOpenAccess W57149703 @default.
• W57149703 hasPrimaryLocation W571497031 @default.
• W57149703 hasRelatedWork W1412057289 @default.
• W57149703 hasRelatedWork W1971426501 @default.
• W57149703 hasRelatedWork W1980910614 @default.
• W57149703 hasRelatedWork W1984306446 @default.
• W57149703 hasRelatedWork W1995391339 @default.
• W57149703 hasRelatedWork W2029697718 @default.
• W57149703 hasRelatedWork W2053126467 @default.
• W57149703 hasRelatedWork W2142633154 @default.
• W57149703 hasRelatedWork W315553456 @default.
• W57149703 hasRelatedWork W2396851661 @default.
• W57149703 isParatext "false" @default.
• W57149703 isRetracted "false" @default.
• W57149703 magId "57149703" @default.
• W57149703 workType "book-chapter" @default.