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- W571844663 abstract "Abstract Polymorphisms in the methylenetetrahydrofolate reductase ( MTHFR ) play important roles in tumor development, progression and metastasis. Moreover, recent studies have reported that a number of 3′-UTR polymorphisms potentially bind to specific microRNAs in a variety of cancers. The aim of this study was to investigate the association of four MTHFR polymorphisms, 2572C>A [rs4846049], 4869C>G [rs1537514], 5488C>T [rs3737967] and 6685T>C [rs4846048] with colorectal cancer (CRC) in Koreans. A total of 850 participants (450 CRC patients and 400 controls) were enrolled in the study. The genotyping of MTHFR 3′-UTR polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism analysis or TaqMan allelic discrimination assay. We found that MTHFR 2572C>A, 4869C>G and 5488C>T genotypes were substantially associated with CRC susceptibility. Of the potentially susceptible polymorphisms, MTHFR 2572C>A was associated with increased homocysteine and decreased folate levels in the plasma based on MTHFR 677CC. Our study provides the evidences for 3′-UTR variants in MTHFR gene as potential biomarkers for use in CRC prevention." @default.
- W571844663 created "2016-06-24" @default.
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- W571844663 date "2015-06-05" @default.
- W571844663 modified "2023-09-24" @default.
- W571844663 title "Genetic variants in 3′-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans" @default.
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- W571844663 doi "https://doi.org/10.1038/srep11006" @default.
- W571844663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4457011" @default.
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