Matches in SemOpenAlex for { <https://semopenalex.org/work/W57184476> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W57184476 endingPage "9" @default.
- W57184476 startingPage "735" @default.
- W57184476 abstract "Studies of tumor invasion and metastasis have focused on the degradation of extracellular matrix (ECM). Matrix metalloproteinases (MMPs), which could degrade ECM, were implicated in cancer invasion and metastasis. Activated MMPs were controlled by specific tissue inhibitors of metalloproteinases (TIMPs). This study was designed to investigate the expression of MMP-2, MMP-9 and TIMP-1, TIMP-2 in human squamous cell carcinomas of uterine cervix, and the association with invasion and metastasis of human squamous cell carcinoma of uterine cervix.Tissue samples from 40 cases of squamous cell carcinoma of the uterine cervix, 29 cases of cervical intraepithelial neoplasia (CIN), and 16 cases of normal cervices were stained immunohistochemically.Immunohistochemical staining of tumor cells for MMP-2, MMP-9, TIMP-1, and TIMP-2 were noted 82.5%, 70.0%, 62.5%, and 97.5% in carcinomas, 44.8%, 62.1%, 86.21%, and 96.55% in CIN lesions respectively, for MMP-2, MMP-9, TIMP-1 in 25.0% normal cervices, but for TIMP-2 in 56.25% normal cervices. There was significant difference for MMP-2 among carcinomas, normal cervices, and CIN respectively (P < 0.01). There was significant difference for MMP-9 among normal cervices, carcinomas, and CIN, respectively (P < 0.05). The positive rates of TIMP-1 and TIMP-2 in the cervical carcinoma group and CIN group were obviously higher than that in normal cervical group(P < 0.01). The positive rates of MMP-2 and MMP-9 in lymph node metastasis were obviously higher than that in without lymph node metastasis(P < 0.01), but for TIMP-2 was contrary and there was no significant difference for TIMP-1. No significant correlation could be established among the expression of these markers and the tumor diameter, the clinical stage, and pathologic grade.The over-expression of MMP-2, MMP-9, TIMP-1, and TIMP-2 may play a key role in invasion and lymph-node metastasis of in squamous carcinoma of the cervix." @default.
- W57184476 created "2016-06-24" @default.
- W57184476 creator A5005058951 @default.
- W57184476 creator A5061959738 @default.
- W57184476 creator A5086763914 @default.
- W57184476 date "2002-07-01" @default.
- W57184476 modified "2023-10-18" @default.
- W57184476 title "[Expression of matrix metalloproteinase-2, 9 and their inhibitor-TIMP 1,2 in human squamous cell carcinoma of uterine cervix]." @default.
- W57184476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12479097" @default.
- W57184476 hasPublicationYear "2002" @default.
- W57184476 type Work @default.
- W57184476 sameAs 57184476 @default.
- W57184476 citedByCount "9" @default.
- W57184476 countsByYear W571844762014 @default.
- W57184476 countsByYear W571844762015 @default.
- W57184476 countsByYear W571844762017 @default.
- W57184476 countsByYear W571844762018 @default.
- W57184476 countsByYear W571844762022 @default.
- W57184476 crossrefType "journal-article" @default.
- W57184476 hasAuthorship W57184476A5005058951 @default.
- W57184476 hasAuthorship W57184476A5061959738 @default.
- W57184476 hasAuthorship W57184476A5086763914 @default.
- W57184476 hasConcept C109523444 @default.
- W57184476 hasConcept C121608353 @default.
- W57184476 hasConcept C126322002 @default.
- W57184476 hasConcept C142724271 @default.
- W57184476 hasConcept C189165786 @default.
- W57184476 hasConcept C204232928 @default.
- W57184476 hasConcept C2777343196 @default.
- W57184476 hasConcept C2777546739 @default.
- W57184476 hasConcept C2777740455 @default.
- W57184476 hasConcept C2778220009 @default.
- W57184476 hasConcept C2779013556 @default.
- W57184476 hasConcept C71924100 @default.
- W57184476 hasConcept C86803240 @default.
- W57184476 hasConcept C95444343 @default.
- W57184476 hasConceptScore W57184476C109523444 @default.
- W57184476 hasConceptScore W57184476C121608353 @default.
- W57184476 hasConceptScore W57184476C126322002 @default.
- W57184476 hasConceptScore W57184476C142724271 @default.
- W57184476 hasConceptScore W57184476C189165786 @default.
- W57184476 hasConceptScore W57184476C204232928 @default.
- W57184476 hasConceptScore W57184476C2777343196 @default.
- W57184476 hasConceptScore W57184476C2777546739 @default.
- W57184476 hasConceptScore W57184476C2777740455 @default.
- W57184476 hasConceptScore W57184476C2778220009 @default.
- W57184476 hasConceptScore W57184476C2779013556 @default.
- W57184476 hasConceptScore W57184476C71924100 @default.
- W57184476 hasConceptScore W57184476C86803240 @default.
- W57184476 hasConceptScore W57184476C95444343 @default.
- W57184476 hasIssue "7" @default.
- W57184476 hasLocation W571844761 @default.
- W57184476 hasOpenAccess W57184476 @default.
- W57184476 hasPrimaryLocation W571844761 @default.
- W57184476 hasRelatedWork W1153654412 @default.
- W57184476 hasRelatedWork W2349529696 @default.
- W57184476 hasRelatedWork W2350149890 @default.
- W57184476 hasRelatedWork W2374336626 @default.
- W57184476 hasRelatedWork W2382678412 @default.
- W57184476 hasRelatedWork W2386030219 @default.
- W57184476 hasRelatedWork W2392604034 @default.
- W57184476 hasRelatedWork W2393396410 @default.
- W57184476 hasRelatedWork W2467703741 @default.
- W57184476 hasRelatedWork W258809401 @default.
- W57184476 hasVolume "21" @default.
- W57184476 isParatext "false" @default.
- W57184476 isRetracted "false" @default.
- W57184476 magId "57184476" @default.
- W57184476 workType "article" @default.