Matches in SemOpenAlex for { <https://semopenalex.org/work/W572123480> ?p ?o ?g. }
- W572123480 endingPage "245" @default.
- W572123480 startingPage "233" @default.
- W572123480 abstract "The ability of microglia to acquire diverse states of activation, or phenotypes, reflects different features that are determinant for their contribution to homeostasis in the adult CNS, and their activity in neuroinflammation, repair or immunomodulation. Despite the widely reported immunomodulatory effects of cannabinoids in both the peripheral immune system and the CNS, less is known about how the endocannabinoid signaling system (eCBSS) influence the microglial phenotype. The general aim of the present study was to investigate the role of endocannabinoids in microglia polarization by using microglia cell cultures. We show that alternative microglia (M2a) and acquired deactivated microglia (M2c) exhibit changes in the eCB machinery that favor the selective synthesis of 2-AG and AEA, respectively. Once released, these eCBs might be able to act through CB1 and/or CB2 receptors in order to influence the acquisition of an M2 phenotype. We present three lines of evidence that the eCBSS is critical for the acquisition of the M2 phenotype: (i) M2 polarization occurs on exposure to the two main endocannabinoids 2-AG and AEA in microglia cultures; (ii) cannabinoid receptor antagonists block M2 polarization; and (iii) M2 polarization is dampened in microglia from CB2 receptor knockout mice. Taken together, these results indicate the interest of eCBSS for the regulation of microglial activation in normal and pathological conditions." @default.
- W572123480 created "2016-06-24" @default.
- W572123480 creator A5036857412 @default.
- W572123480 creator A5038334321 @default.
- W572123480 creator A5038429207 @default.
- W572123480 creator A5052791762 @default.
- W572123480 creator A5064712625 @default.
- W572123480 creator A5078740675 @default.
- W572123480 creator A5083968219 @default.
- W572123480 date "2015-10-01" @default.
- W572123480 modified "2023-10-17" @default.
- W572123480 title "Endocannabinoids drive the acquisition of an alternative phenotype in microglia" @default.
- W572123480 cites W1517915610 @default.
- W572123480 cites W1547047907 @default.
- W572123480 cites W1550754406 @default.
- W572123480 cites W1591647183 @default.
- W572123480 cites W1606443939 @default.
- W572123480 cites W1833126618 @default.
- W572123480 cites W1928931031 @default.
- W572123480 cites W1964404756 @default.
- W572123480 cites W1968591685 @default.
- W572123480 cites W1968740815 @default.
- W572123480 cites W1970077719 @default.
- W572123480 cites W1994861382 @default.
- W572123480 cites W2006730284 @default.
- W572123480 cites W2007485514 @default.
- W572123480 cites W2007663366 @default.
- W572123480 cites W2012624148 @default.
- W572123480 cites W2016078643 @default.
- W572123480 cites W2021799361 @default.
- W572123480 cites W2023366312 @default.
- W572123480 cites W2028794471 @default.
- W572123480 cites W2038689279 @default.
- W572123480 cites W2044344430 @default.
- W572123480 cites W2045531190 @default.
- W572123480 cites W2057976080 @default.
- W572123480 cites W2059254350 @default.
- W572123480 cites W2059994807 @default.
- W572123480 cites W2060023076 @default.
- W572123480 cites W2063155826 @default.
- W572123480 cites W2077322233 @default.
- W572123480 cites W2081137833 @default.
- W572123480 cites W2097747770 @default.
- W572123480 cites W2101898118 @default.
- W572123480 cites W2103247095 @default.
- W572123480 cites W2103617764 @default.
- W572123480 cites W2104372351 @default.
- W572123480 cites W2106105150 @default.
- W572123480 cites W2111152176 @default.
- W572123480 cites W2111572664 @default.
- W572123480 cites W2117464417 @default.
- W572123480 cites W2118835279 @default.
- W572123480 cites W2119826244 @default.
- W572123480 cites W2123640179 @default.
- W572123480 cites W2126304984 @default.
- W572123480 cites W2126766019 @default.
- W572123480 cites W2132259121 @default.
- W572123480 cites W2134046076 @default.
- W572123480 cites W2139530080 @default.
- W572123480 cites W2146204370 @default.
- W572123480 cites W2149200346 @default.
- W572123480 cites W2150675101 @default.
- W572123480 cites W2150954514 @default.
- W572123480 cites W2154142977 @default.
- W572123480 cites W2159442019 @default.
- W572123480 cites W2166806732 @default.
- W572123480 cites W2170706621 @default.
- W572123480 cites W2170959966 @default.
- W572123480 cites W2337972680 @default.
- W572123480 cites W2968926214 @default.
- W572123480 cites W4231754436 @default.
- W572123480 doi "https://doi.org/10.1016/j.bbi.2015.06.002" @default.
- W572123480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26086345" @default.
- W572123480 hasPublicationYear "2015" @default.
- W572123480 type Work @default.
- W572123480 sameAs 572123480 @default.
- W572123480 citedByCount "158" @default.
- W572123480 countsByYear W5721234802015 @default.
- W572123480 countsByYear W5721234802016 @default.
- W572123480 countsByYear W5721234802017 @default.
- W572123480 countsByYear W5721234802018 @default.
- W572123480 countsByYear W5721234802019 @default.
- W572123480 countsByYear W5721234802020 @default.
- W572123480 countsByYear W5721234802021 @default.
- W572123480 countsByYear W5721234802022 @default.
- W572123480 countsByYear W5721234802023 @default.
- W572123480 crossrefType "journal-article" @default.
- W572123480 hasAuthorship W572123480A5036857412 @default.
- W572123480 hasAuthorship W572123480A5038334321 @default.
- W572123480 hasAuthorship W572123480A5038429207 @default.
- W572123480 hasAuthorship W572123480A5052791762 @default.
- W572123480 hasAuthorship W572123480A5064712625 @default.
- W572123480 hasAuthorship W572123480A5078740675 @default.
- W572123480 hasAuthorship W572123480A5083968219 @default.
- W572123480 hasConcept C104317684 @default.
- W572123480 hasConcept C127716648 @default.
- W572123480 hasConcept C148001335 @default.
- W572123480 hasConcept C169760540 @default.