Matches in SemOpenAlex for { <https://semopenalex.org/work/W572461520> ?p ?o ?g. }
- W572461520 abstract "The genetic basis of cardiovascular disease (CVD) with its complex etiology is still largely elusive. Plasma levels of lipids and apolipoproteins are among the major quantitative risk factors for CVD and are well-established intermediate traits that may be more accessible to genetic dissection than clinical CVD endpoints. To identify quantitative trait loci influencing lipid and apolipoprotein levels in the general population, we performed a genome scan with an intermarker distance of 18 cM in four independent samples including adolescent Dutch twins and adult Dutch, Swedish and Australian twins totalling 493 dizygotic twin pairs. Chromosomes 1, 2, 6, 7, 8, 11, 15, 16, 17, and 19 were analysed for linkage (the other chromosomes are currently scanned). These chromosomes harbour candidate genes for lipid and apolipoprotein levels, including two known quantitative trait loci: the LPA locus on chromosome 6q27 is known to explain approximately 90% of the population variation in Lp(a) plasma levels and the APOE locus on chromosome 19q13.32 explains approximately 15% of apoE plasma levels. These two loci were tested for linkage to investigate whether QTLs with major as well as moderate effects can be detected using our genome scanning protocol. In this paper, we report 4 significant linkage results, i.e. maximum LOD scores (MLS) higher than 3.6 and 7 suggestive linkage results, i.e. MLS between 2.2 and 3.6. Since we have unique samples to test for replication of linkage results, we also report linkage results with MLS higher than 2.2 in one twin sample and MLS higher than 1.4 in an other twin samples within 20 cM for the same trait. Potentially interesting loci, include putative Lp(a) QTLs on chromosome 1 and 2, a putative apoB QTL on chromosome 11, and a putative QTL on chromosome 19 influencing LDL cholesterol levels. 4" @default.
- W572461520 created "2016-06-24" @default.
- W572461520 creator A5091878346 @default.
- W572461520 date "2004-01-01" @default.
- W572461520 modified "2023-09-26" @default.
- W572461520 title "Towards mapping QTLs : influencing parameters of lipid metabolism in human twins" @default.
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