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- W57280003 abstract "The complexation of piroxicam with various cyclodextrins was studied in the whole pH range, in an attempt to clarify the reported differences in stoichiometry of the resulting inclusion complexes. In this work, it was found that the pH dependent self-association phenomena, detected in both alkaline and acidic media, are the defining features for complex stoichiometry. Also, it was observed that the inclusion complexes of the piroxicam zwitterion with beta-cyclodextrin (beta CD), methyl-beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin have a 2:2 stoichiometry in acidic pH, through inclusion of the benzyl ring moiety. As pH increased, it was determined that the different ionic state of the molecules creates new geometries, involving also the pyridyl-ring in the complexation. More stable inclusion complexes of 2:5 stoichiometry are observed at pH>4. A reversed phase liquid chromatography method, specific for the analysis of the included piroxicam, was developed and validated. The different stoichiometries and the dimers formation were investigated by interpretation of the two-dimensional 1H NMR spectroscopy." @default.
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- W57280003 date "2004-04-01" @default.
- W57280003 modified "2023-10-05" @default.
- W57280003 title "The effect of pH dependent molecular conformation and dimerization phenomena of piroxicam on the drug:cyclodextrin complex stoichiometry and its chromatographic behaviour" @default.
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- W57280003 doi "https://doi.org/10.1016/j.ejps.2004.01.007" @default.
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