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- W572840220 abstract "Objective:To examine the effects of troglitazone(TGZ),agonist of peroxisome proliferator-activated receptor-γ(PPARγ),on the growth and growth hormone(GH) secretion of pituitary adenoma cells,and to expolre the possible mechanism.Methods:The inhibitory effect of TGZ on the proliferation and GH secretion of rat pituitary adenoma cell line GH3 was detected by MTT assay and ELISA.Furthermore,apoptosis,cell cycle as well as caspase-3,Bcl-2 and Bax expression of GH3 cells were examined by transmission electron microscopy,flow cytometry and Western blotting,respectively.Results:TGZ dose-and time-dependently inhibited the proliferation and GH secretion of GH3 cells.GH3 cells treated with TGZ had a typical morphological characteristic of apoptosis.CH3 cell number in G_1 phase was increased and cell number in G_2,S phases was significantly decreased after treatment with TGZ.The expression of caspase-3 and Bax in CH3 cells was significantly increased and Bcl-2 expression was markedly decreased in a dose-dependent manner after treatment with TGZ.Conclusion:PPARγ agonist inhibits the growth and GH secretion of pituitary adenoma cells through inducing apoptosis and cell cycle arresting." @default.
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- W572840220 date "2009-01-01" @default.
- W572840220 modified "2023-09-26" @default.
- W572840220 title "Troglitazone inhibits growth of pituitary adenoma GH3 cells and the involved mechanisms" @default.
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