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- W57421243 abstract "A key challenge in cancer genomics is the identification and prioritization of genomic aberrations that potentially act as drivers of cancer. HIT’nDRIVE is a combinatorial method to identify aberrant genes that can collectively influence possibly distant “outlier” genes based on the “random-walk facility location” (RWFL) problem on an interaction network. RWFL uses “multi-hitting time”, the expected minimum length of a random walk originating from any aberrant gene towards an outlier. HIT’nDRIVE aims to find the smallest set of aberrant genes from which one can reach outliers within desired multi-hitting time. It estimates multi-hitting time based on the independent hitting times and reduces the RWFL to a weighted multi-set cover problem, which it solves as an integer linear program (ILP). We apply HIT’nDRIVE to identify aberrant genes that potentially act as drivers in a cancer data set and make phenotype predictions using only the potential drivers, more accurately than alternative approaches. keywords: drivers, cancer, multi-hitting time, interaction networks, multi-set cover" @default.
- W57421243 created "2016-06-24" @default.
- W57421243 creator A5083431950 @default.
- W57421243 date "2014-08-22" @default.
- W57421243 modified "2023-09-27" @default.
- W57421243 title "Multi-driver gene prioritization based on hitting time" @default.
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