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- W574309163 abstract "Purpose: To characterize the pupil light reflex (PLR), electroretinographic (ERG) and tonometric parameters in healthy rat eyes. Methods: Brown Norway rats were used for experiments. The PLR was evaluated with a computerized pupillomotor (n=27), ERGs were recorded simultaneously from both eyes (n=27) and IOP was measured with a Tonopen (n=15). Results: The analysis of the PLR parameters confirmed the consensual PLR was significantly smaller in amplitude (p=0.03) and increased latency time (p=0.001 ) compared to the direct PLR. Electroretinography (1600+200 cd/m2) revealed a-wave amplitude of 207.2+13 jiV and the b-wave 554.3+24.5 |iV. The flicker ERG recording revealed amplitudes of 40.6+2.4 fiV. Tonometry measurements revealed that isoflurane, but not halothane, anesthesia suppressed the IOP (non-anesthetized: 25.3+1.0 mmHg; 1% halothane+30% NO: 26.2+1.1 (p>0.05); 1% isoflurane+30% NO: 20.1+1.6 (p<0.05)). Conclusions: Consensual PLR in rats has a relative deficit comparing to the direct PLR. Isoflurane anesthesia has suppressive effect on the IOP in healthy rat eyes." @default.
- W574309163 created "2016-06-24" @default.
- W574309163 creator A5005323368 @default.
- W574309163 date "2018-08-13" @default.
- W574309163 modified "2023-10-16" @default.
- W574309163 title "Functional characterization of retina and optic nerve after acute and chronic elevation of the intraocular pressure in rats" @default.
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- W574309163 doi "https://doi.org/10.31274/rtd-180813-12145" @default.
- W574309163 hasPublicationYear "2018" @default.
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