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- W574419361 abstract "TRPV1 is a heat and ligand-gated ion channel, and the sensory ganglion neurons that express TRPV1 are key elements at the start of the pain pathway. Elucidating the physiological and neurobiological mechanisms underlying the role of TRPV1 in primary afferent neurons led to the idea that highly selective chemoablation of TRPV1-containing peripheral nerve endings, or the entire TRPV1-expressing neuron itself, could be used to control pain. Selective lesion of the TRPV1-expressing nociceptive primary afferent population has the advantage of sparing motor, proprioceptive, and other somatosensory functions that are so important for coordinated movement, performing activities of daily living, and maintaining quality of life. This chapter examines the mechanisms underlying the therapeutic use of agonists, notably the potent TRPV1 agonist resiniferatoxin, the advantages and constraints imposed by TRPV1 agonist actions, and examples of such use in clinical veterinary and human pain." @default.
- W574419361 created "2016-06-24" @default.
- W574419361 creator A5000790699 @default.
- W574419361 creator A5006333981 @default.
- W574419361 date "2015-01-01" @default.
- W574419361 modified "2023-10-18" @default.
- W574419361 title "TRPV1 Agonist Cytotoxicity for Chronic Pain Relief" @default.
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- W574419361 doi "https://doi.org/10.1016/b978-0-12-420024-1.00006-0" @default.
- W574419361 hasPublicationYear "2015" @default.
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