Matches in SemOpenAlex for { <https://semopenalex.org/work/W57505563> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W57505563 endingPage "2686" @default.
- W57505563 startingPage "2683" @default.
- W57505563 abstract "The effect of tumor promoter phorbol esters on cell proliferation was investigated in human breast cancer cell line MCF-7. During a 4-day culture period, the various phorbol ester derivatives TPA, PDD, PDBu, PDBz and PDA inhibited the proliferation of MCF-7 cells in a dose-dependent manner, with respective IC50 of 0.06, 0.75, 2.4, 3.6 and 15 × 10−9 M. The 4-O-met-TPA, αPDD and αPHR were ineffective at 2 × 10−7 M, the highest concentration tested. Using a 3H-PDBu probe, we demonstrated the presence of specific, high affinity binding sites in intact cultured cells, with a Kd of about 9 × 10−9 M. Unlabelled TPA, PDD, PDBU and PDBz competed with 3H-PDBu with respective ic50 of 35, 12.5, 150 and 220 × 10−9 M. High concentrations of PDA, 4-O-met-TPA and αPDD slightly inhibited the 3H PDBu binding, whereas αPHR did not until 10−5 M. The correlation that we observed between the relative potencies of the various phorbol derivatives for inhibiting both PDBu binding and cell proliferation, suggests that tumor promoter phorbol esters may induce growth arrest in MCF-7 cells by the mediation of protein kinase C." @default.
- W57505563 created "2016-06-24" @default.
- W57505563 creator A5037421002 @default.
- W57505563 creator A5055965666 @default.
- W57505563 creator A5079483585 @default.
- W57505563 date "1986-08-01" @default.
- W57505563 modified "2023-10-01" @default.
- W57505563 title "Phorbol esters inhibit the proliferation of MCF-7 cells" @default.
- W57505563 cites W142482983 @default.
- W57505563 cites W1495721887 @default.
- W57505563 cites W1569108584 @default.
- W57505563 cites W1577309327 @default.
- W57505563 cites W1585242164 @default.
- W57505563 cites W1594758412 @default.
- W57505563 cites W1969665533 @default.
- W57505563 cites W1988803304 @default.
- W57505563 cites W2015916398 @default.
- W57505563 cites W2029770423 @default.
- W57505563 cites W2039014436 @default.
- W57505563 cites W2053787081 @default.
- W57505563 cites W2069501076 @default.
- W57505563 cites W2083517465 @default.
- W57505563 cites W2095723732 @default.
- W57505563 cites W2196524012 @default.
- W57505563 doi "https://doi.org/10.1016/0006-2952(86)90175-9" @default.
- W57505563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3461788" @default.
- W57505563 hasPublicationYear "1986" @default.
- W57505563 type Work @default.
- W57505563 sameAs 57505563 @default.
- W57505563 citedByCount "45" @default.
- W57505563 crossrefType "journal-article" @default.
- W57505563 hasAuthorship W57505563A5037421002 @default.
- W57505563 hasAuthorship W57505563A5055965666 @default.
- W57505563 hasAuthorship W57505563A5079483585 @default.
- W57505563 hasConcept C109541995 @default.
- W57505563 hasConcept C11960822 @default.
- W57505563 hasConcept C121608353 @default.
- W57505563 hasConcept C126322002 @default.
- W57505563 hasConcept C153911025 @default.
- W57505563 hasConcept C185592680 @default.
- W57505563 hasConcept C195794163 @default.
- W57505563 hasConcept C202751555 @default.
- W57505563 hasConcept C2777752497 @default.
- W57505563 hasConcept C2779707156 @default.
- W57505563 hasConcept C2780043322 @default.
- W57505563 hasConcept C2994423619 @default.
- W57505563 hasConcept C3017695315 @default.
- W57505563 hasConcept C54355233 @default.
- W57505563 hasConcept C55493867 @default.
- W57505563 hasConcept C62112901 @default.
- W57505563 hasConcept C71924100 @default.
- W57505563 hasConcept C81885089 @default.
- W57505563 hasConcept C86803240 @default.
- W57505563 hasConcept C96232424 @default.
- W57505563 hasConceptScore W57505563C109541995 @default.
- W57505563 hasConceptScore W57505563C11960822 @default.
- W57505563 hasConceptScore W57505563C121608353 @default.
- W57505563 hasConceptScore W57505563C126322002 @default.
- W57505563 hasConceptScore W57505563C153911025 @default.
- W57505563 hasConceptScore W57505563C185592680 @default.
- W57505563 hasConceptScore W57505563C195794163 @default.
- W57505563 hasConceptScore W57505563C202751555 @default.
- W57505563 hasConceptScore W57505563C2777752497 @default.
- W57505563 hasConceptScore W57505563C2779707156 @default.
- W57505563 hasConceptScore W57505563C2780043322 @default.
- W57505563 hasConceptScore W57505563C2994423619 @default.
- W57505563 hasConceptScore W57505563C3017695315 @default.
- W57505563 hasConceptScore W57505563C54355233 @default.
- W57505563 hasConceptScore W57505563C55493867 @default.
- W57505563 hasConceptScore W57505563C62112901 @default.
- W57505563 hasConceptScore W57505563C71924100 @default.
- W57505563 hasConceptScore W57505563C81885089 @default.
- W57505563 hasConceptScore W57505563C86803240 @default.
- W57505563 hasConceptScore W57505563C96232424 @default.
- W57505563 hasIssue "16" @default.
- W57505563 hasLocation W575055631 @default.
- W57505563 hasLocation W575055632 @default.
- W57505563 hasOpenAccess W57505563 @default.
- W57505563 hasPrimaryLocation W575055631 @default.
- W57505563 hasRelatedWork W2009280429 @default.
- W57505563 hasRelatedWork W2029870587 @default.
- W57505563 hasRelatedWork W2051620413 @default.
- W57505563 hasRelatedWork W2070570709 @default.
- W57505563 hasRelatedWork W2079600272 @default.
- W57505563 hasRelatedWork W2083424038 @default.
- W57505563 hasRelatedWork W2093309311 @default.
- W57505563 hasRelatedWork W2096358361 @default.
- W57505563 hasRelatedWork W2226253281 @default.
- W57505563 hasRelatedWork W57505563 @default.
- W57505563 hasVolume "35" @default.
- W57505563 isParatext "false" @default.
- W57505563 isRetracted "false" @default.
- W57505563 magId "57505563" @default.
- W57505563 workType "article" @default.