Matches in SemOpenAlex for { <https://semopenalex.org/work/W57510132> ?p ?o ?g. }
- W57510132 endingPage "1095" @default.
- W57510132 startingPage "1087" @default.
- W57510132 abstract "Despite general agreement about the boundaries of Alzheimer disease (AD), establishing a maximum limit for Alzheimer-type pathology in cognitively intact individuals might aid in defining more precisely the point at which Alzheimer pathology becomes clinically relevant. In this study, we examined the neuropathological changes in the brains of 39 longitudinally followed. cognitively normal elderly individuals (24 women, 15 men; age range 74-95, median 85 years). Neuropathological changes of the Alzheimer type were quantified by determining neurofibrillary tangle (NFT) staging by the method of Braak and Braak and by quantification of the abundance of diffuse, cored, and neuritic plaque burden using the scheme developed by the Consortium to Establish a Registry for Alzheimer Disease (CERAD). Vascular, Lewy body, and argyrophilic grain pathology were also assessed. We found 34 subjects (87%) with a Braak stage <IV; 32 subjects (82%) with less than moderate numbers of cored plaques and 37 subjects (95%) with less than moderate numbers of tau-positive neuritic plaques. Many subjects had moderate or frequent diffuse plaques (n = 19, 49%). By the National Institute on Aging-Reagan Institute (NIA-RI) criteria, none of our cases met criteria for high likelihood of AD. Four met NIA-RI criteria for intermediate likelihood. Seven cases met CERAD criteria for possible AD. Nineteen met Khachaturian criteria for AD. Only 1 subject had neocortical Lewy bodies. Small, old infarcts were common, but no subjects had more than 2 of these and none had a single large infarction. Thus, the majority of individuals who are cognitively normal near the time of their death have minimal amounts of tau-positive neuritic pathology (Braak stage <IV and neuritic plaques <6 per x100 field in the most affected neocortical region). The few subjects with more severe AD pathology can be expected based on incidence rates of AD in the very elderly." @default.
- W57510132 created "2016-06-24" @default.
- W57510132 creator A5004201320 @default.
- W57510132 creator A5009533777 @default.
- W57510132 creator A5016965073 @default.
- W57510132 creator A5034375731 @default.
- W57510132 creator A5038013244 @default.
- W57510132 creator A5045246745 @default.
- W57510132 creator A5045283968 @default.
- W57510132 creator A5045667080 @default.
- W57510132 creator A5053703908 @default.
- W57510132 creator A5059027860 @default.
- W57510132 creator A5066352714 @default.
- W57510132 creator A5076444858 @default.
- W57510132 creator A5079072353 @default.
- W57510132 date "2003-11-01" @default.
- W57510132 modified "2023-10-12" @default.
- W57510132 title "Neuropathology of Cognitively Normal Elderly" @default.
- W57510132 cites W1556490889 @default.
- W57510132 cites W1870043354 @default.
- W57510132 cites W1963568158 @default.
- W57510132 cites W1968401437 @default.
- W57510132 cites W1971855939 @default.
- W57510132 cites W1972340735 @default.
- W57510132 cites W1974005435 @default.
- W57510132 cites W1979755700 @default.
- W57510132 cites W1980842500 @default.
- W57510132 cites W1983611639 @default.
- W57510132 cites W2002317851 @default.
- W57510132 cites W2009882167 @default.
- W57510132 cites W2014670147 @default.
- W57510132 cites W2023649381 @default.
- W57510132 cites W2039210191 @default.
- W57510132 cites W2039664444 @default.
- W57510132 cites W2040073110 @default.
- W57510132 cites W2046980496 @default.
- W57510132 cites W2052742260 @default.
- W57510132 cites W2053116497 @default.
- W57510132 cites W2055101973 @default.
- W57510132 cites W2056739376 @default.
- W57510132 cites W2056976370 @default.
- W57510132 cites W2058740898 @default.
- W57510132 cites W2061495142 @default.
- W57510132 cites W2065535274 @default.
- W57510132 cites W2070137740 @default.
- W57510132 cites W2072691846 @default.
- W57510132 cites W2072753569 @default.
- W57510132 cites W2082665846 @default.
- W57510132 cites W2091369856 @default.
- W57510132 cites W2102447768 @default.
- W57510132 cites W2104934386 @default.
- W57510132 cites W2123056519 @default.
- W57510132 cites W2132881915 @default.
- W57510132 cites W2163665026 @default.
- W57510132 cites W2171405125 @default.
- W57510132 cites W4248875019 @default.
- W57510132 doi "https://doi.org/10.1093/jnen/62.11.1087" @default.
- W57510132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14656067" @default.
- W57510132 hasPublicationYear "2003" @default.
- W57510132 type Work @default.
- W57510132 sameAs 57510132 @default.
- W57510132 citedByCount "562" @default.
- W57510132 countsByYear W575101322012 @default.
- W57510132 countsByYear W575101322013 @default.
- W57510132 countsByYear W575101322014 @default.
- W57510132 countsByYear W575101322015 @default.
- W57510132 countsByYear W575101322016 @default.
- W57510132 countsByYear W575101322017 @default.
- W57510132 countsByYear W575101322018 @default.
- W57510132 countsByYear W575101322019 @default.
- W57510132 countsByYear W575101322020 @default.
- W57510132 countsByYear W575101322021 @default.
- W57510132 countsByYear W575101322022 @default.
- W57510132 countsByYear W575101322023 @default.
- W57510132 crossrefType "journal-article" @default.
- W57510132 hasAuthorship W57510132A5004201320 @default.
- W57510132 hasAuthorship W57510132A5009533777 @default.
- W57510132 hasAuthorship W57510132A5016965073 @default.
- W57510132 hasAuthorship W57510132A5034375731 @default.
- W57510132 hasAuthorship W57510132A5038013244 @default.
- W57510132 hasAuthorship W57510132A5045246745 @default.
- W57510132 hasAuthorship W57510132A5045283968 @default.
- W57510132 hasAuthorship W57510132A5045667080 @default.
- W57510132 hasAuthorship W57510132A5053703908 @default.
- W57510132 hasAuthorship W57510132A5059027860 @default.
- W57510132 hasAuthorship W57510132A5066352714 @default.
- W57510132 hasAuthorship W57510132A5076444858 @default.
- W57510132 hasAuthorship W57510132A5079072353 @default.
- W57510132 hasConcept C142724271 @default.
- W57510132 hasConcept C15744967 @default.
- W57510132 hasConcept C2776477761 @default.
- W57510132 hasConcept C2779134260 @default.
- W57510132 hasConcept C2779483572 @default.
- W57510132 hasConcept C2779721402 @default.
- W57510132 hasConcept C2780130745 @default.
- W57510132 hasConcept C502032728 @default.
- W57510132 hasConcept C68026918 @default.
- W57510132 hasConcept C71924100 @default.